CAS: 122918-25-6; 6-Bromopicolinonitrile

相似化合物

34160-40-2 21190-87-4 25194-52-9

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CAS号25194-52-9 6-溴吡啶甲酰胺 | CAS号34160-40-2 6-溴吡啶-2-甲醛 | CAS号21190-87-4 6-溴-2-吡啶羧酸 | CAS号4392-85-2 2,2'-二吡啶-6-甲腈 | CAS号120613-15-2 6-乙烯基-2-吡啶腈 | CAS号833457-45-7 6-[3-(trifluoro... | CAS号4411-83-0 6,6'-二氰基-2,2'-联吡啶

6-溴吡啶-2-甲醛置于盐酸羟胺,三乙胺,三光气体系中,用 氯仿 用作溶剂,以67%的收率获得2-溴-6-氰基吡啶
参考文献:喷他idine的吡啶基类似物的合成及抗原生动物活性
标题:喷他idine的吡啶基类似物的合成及抗原生动物活性
摘要:一系列新颖的吡啶基类似物的1-18抗原虫药物1,5-双(4-脒基苯氧基)戊烷(戊烷脒)已被合成,并且在针对体外活性测试布氏锥虫罗得西亚,恶性疟原虫,和杜氏利什曼原虫,和细胞毒性对抗哺乳动物细胞.化合物的抗原生动物性质1-18取决于阳离子部分上的吡啶环的放置以及取代基对脒基团的性质.具有与吡啶氮原子相邻的阳离子部分的二m 6是该系列中最有前途的化合物,显示出优异的体外活性t. Brucei Rhodesiense,P.Falciparum和l. Donovani与喷他idine比较.每天以25 Mg / Kg的剂量连续服用4天的二am胺6,泛亚胺肟9口服前体药物在体内治愈锥虫病的stib900急性小鼠模型中的所有受感染动物均表现出优异的抗锥虫功效.
Doi:10.1021/jm900805V

专利信息

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:CN-109232343-A
优先权日:2018-10-24
标 题 :A method for copper-catalyzed synthesis of aromatic/alkane 2,2,2-trifluoroethyl selenide and its application in pesticides

专利号:CN-109232343-B
优先权日:2018-10-24
标 题:A method for copper-catalyzed synthesis of aromatic/alkane 2,2,2-trifluoroethyl selenide and its application in pesticides

专利号:US-11858943-B2
优先权日:2017-06-05
标题:Vasopressin receptor antagonists and products and methods related thereto
发明人：JONES ROBERT M; URBANO MARIANGELA; BRANDT GARY; HARDICK DAVID; KNIGHT CHRIS; TIERNEY JASON
权利人:NEUMORA THERAPEUTICS INC
摘要:Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:wherein A, B, G, R1, R1b, R1c, R2 and X are as defined herein.

专利号:CN-119708004-A
优先权日:2025-03-03
标 题:A synthesis method and application of clopidogrel hydrogen sulfate impurity B