CAS: 14002-80-3; Methyl 3-Hydroxy-2,2-Dimethylpropanoate

该化合物是一种多用途酯化合物,广泛用于有机合成和工业应用,其主要优点包括作为生产特殊化学品的中间体,如增塑剂,涂料和粘合剂,具有高度的再活性.该化合物的酯功能和氢氧基组可有效修改定制化学工艺.HPAME在普通有机溶剂中表现出良好的溶解性,便于其融入配方.在典型的反应条件下,其稳定性是合成应用的可靠选择.此外,它作为精细化学品的前体,有助于其在制药和农用化学制造中的效用.该化合物的价值是其反应性和处理特性的平衡.

结构式图片

相似化合物

4835-90-9 17701-61-0 361547-56-0

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上下游产品

CAS号50-00-0 甲醛 | CAS号31469-15-5 1-甲氧基-2-甲基-1-(三... | CAS号4835-90-9 羟基特戊酸 | CAS号67-56-1 甲醇 | CAS号597-31-9 2,2-二甲基-3-羟基丙醛 | CAS号13511-38-1 3-氯特戊酸 | CAS号126-30-7 新戊二醇(NPG) | CAS号58653-91-1 Isobuttersaeure... | CAS号85433-67-6 methyl lithiois... | CAS号23426-63-3 2-溴异丁酸甲酯 | CAS号104963-55-5 (3-chloro-2,2-d... | CAS号280586-19-8 3-(4-methoxyphe... | CAS号25307-88-4 methyl 3-methox... | CAS号130432-36-9 2,2-二甲基-3-(硝基氧基)丙酸 | CAS号4835-90-9 羟基特戊酸 | CAS号126-30-7 新戊二醇(NPG) | CAS号13865-20-8 2,2-二甲基-3-氧代丙酸甲酯 | CAS号19036-43-2 3-氨基-2,2二甲基乙酸 | CAS号650625-31-3 2-[(2,2-dimethy... | CAS号66582-32-9 3-(苄氧基)-2,2-二甲基-1-丙醇

合成工艺路线路线简述

    3-氯-2,2-二甲基丙酸 以 甲醇,Sodium Methylate 用作溶剂,化学反应生成羟基三甲基乙酸甲酯
    参考文献:Herbicidal 3-Isoxazolidinones And Hydroxamic Acids
    标题:Herbicidal 3-Isoxazolidinones And Hydroxamic Acids
    摘要:新型3-异噁唑烷酮化合物和新型羟羧酸中间体表现出对禾本科和阔叶植物种类的除草活性,同时不影响豆科植物,特别是大豆.这些化合物的制备和除草活性得到了示范.

    海关参考信息

    专利信息


    专利号:US-8314246-B2
    优先权日:2005-08-30
    标题:Catalytic reactions involving alkenes
    发明人:JAMISON TIMOTHY F; NG SZE-SZE
    权利人:JAMISON TIMOTHY F; NG SZE-SZE; MASSACHUSETTS INST TECHNOLOGY
    摘要:The present invention relates to new compositions and reactions to produce allylic alcohols or precursors of allylic alcohols (e.g., silyl ethers of allylic alcohols). Methods of the invention may comprise combining an alkene and an aldehyde in the presence of a transition metal catalyst (e.g., a nickel catalyst) to form an allylic alcohol or precursor of an allylic alcohol. Reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. Also, methods of the invention may be useful as fragment coupling reactions in complex molecule synthesis. Moreover, methods of the invention may include the use of reagents which, under reaction conditions known in the art, may have been unreactive, i.e., may not have been able to form the reaction product. The reagents used in the present invention may be relatively lower in cost than in other methods. Also, methods of the invention may reduce the number of synthetic and purification steps required to produce the reaction products, as well as reducing time, cost, and waste production.

    专利号:US-8178559-B2
    优先权日:2004-12-30
    标 题:Organic compounds
    发明人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
    权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
    摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

    专利号:US-7807709-B2
    优先权日:2005-03-23
    标题 :Organic compounds
    发明人:EHRHARDT CLAUS; IRIE OSAMU; LORTHIOIS EDWIGE LILIANE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER
    权利人:NOVARTIS AG
    摘要:The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis.

    专利号:US-9133224-B2
    优先权日:2010-11-29
    标 题:Macrocyclic kinase inhibitors
    发明人:CREW ANDREW P; DONG HANQING; FERRARO CATERINA; SHERMAN DAN; SIU KAM W
    权利人:CREW ANDREW P; DONG HANQING; FERRARO CATERINA; SHERMAN DAN; SIU KAM W; OSI PHARMACEUTICALS LLC
    摘要:Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.

    专利号:US-7825149-B2
    优先权日:2006-01-19
    标 题 :Substituted imidazoles
    发明人:CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
    权利人:PFIZER LTD
    摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

    专利号:CN-110498915-B
    优先权日:2019-07-16
    标 题:A simple and controllable synthesis method of α-carboxy-ω-hydroxy polyether
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    主要参考文献

    [参考文献]: Alexandra Rotinov, Et Al. Joint Experimental And Theoretical Studies Of The Mechanism For The Gas Phase Elimination Kinetics Of Methyl 2,2-Dimethyl-3-Hydroxypropionate. J Phys Chem A. 2009 Apr 16;113(15):3491-7.

    合成参考文献


    参考文献:10.1007/s00792-018-1004-0
    摘要:Yoneda K, Sakuraba H, Araki T, Ohshima T. Crystal structure of the NADP+ and tartrate-bound complex of L-serine 3-dehydrogenase from the hyperthermophilic archaeon Pyrobaculum calidifontis. Extremophiles. 2018 May;22(3):395–405. doi: 10.1007/s00792-018-1004-0.
    参考文献:10.1016/j.jsbmb.2004.03.053
    摘要:Fujishima T, Kittaka A, Kurihara M, Saito N, Honzawa S, Kishimoto S, Sugiura T, Waku K, Takayama H. 2,2-Functionalized analogues of 1α,25-dihydroxyvitamin D3, the potent inducers of cell differentiation. The Journal of Steroid Biochemistry and Molecular Biology. 2004 May;89-90():89–92. doi: 10.1016/j.jsbmb.2004.03.053.
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