CAS: 1428243-26-8; Benzyl (3R,4S)-3-(2-Bromoacetyl)-4-Ethylpyrrolidine-1-Carboxylate

相似化合物

2304514-60-9 2304514-69-8 1708997-41-4

上下游产品

(3R,4S)-1-((苄氧羰基)-4-乙基吡咯烷-3-羧酸 (3R,4S)-1-((Benzyloxy)Carbonyl)-4-Ethylpyrrolidine-3-Carboxylate 1428243-24-6
N-Cbz-4-氧代-3-吡咯烷甲酸乙酯 1-Benzyl 3-Ethyl 4-Oxopyrrolidine-1,3-Dicarboxylate 51814-19-8

N-Cbz-甘氨酸乙酯置于n-甲基吗啉,Ruthenium Diacetate (S) Segphos,水,氢溴酸,氢气,溴,Potassium Carbonate,1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三乙胺,Sodium Hydroxide,Sodium T-Butanolate体系中,用 四氢呋喃,甲醇,二氯甲烷,水,甲苯 用作溶剂,化学反应 93.0H,反应生成(3R,4S)-3-(2-溴乙酰基)-4-乙基-1-吡咯烷羧酸苄酯
参考文献: The Process For The Preparation Of Upadacitinib And Its Intermediates[fr] Procédé De Préparation D'Upadacitinib Et De Ses Intermédiaires
标题: The Process For The Preparation Of Upadacitinib And Its Intermediates[fr] Procédé De Préparation D'Upadacitinib Et De Ses Intermédiaires
摘要:本发明提供了一种通过使用新型中间体制备upadacitinib的改进工艺.本发明还提供了制备upadacitinib的新型中间体的工艺.

专利信息

专利号:US-11976077-B2
优先权日:2015-10-16
标 题 :Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms therof
发明人：PANGAN AILEEN L; TEIXEIRA HENRIQUE D; MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A; KLÃœNDER BEN; VOSS JEFFREY W; PADLEY ROBERT J; CAMP HEIDI S
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

专利号:US-9963459-B1
优先权日:2015-10-16
标 题:Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-alpla]pyrrolo[2,3-e]-pyrazin-8-YL)-N-(2,2,2-Trifluoroethyl)pyrrol and solid state forms thereof
发明人：JAYANTH JAYANTHY; MARROUM PATRICK J; MAYER PETER T; MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

专利号:CN-119119058-A
优先权日:2023-06-13
标题:Synthesis method of Marpatinib, intermediate and preparation method of intermediate