CAS: 15513-48-1; 4-Chloro-2,6-Dimethyl-3-Nitropyridine

相似化合物

23056-35-1 282102-05-0 37652-11-2

上下游产品

2,6-dimethyl-3-nitro-4(1H)-pyridone 2,6-dimethyl-4-hydroxy-3-nitropyridine 2,6-dimethylpyrone 2,6-dimethyl-1H-pyridin-4-one 4-iodo-2,6-dimethyl-3-nitropyridine 4-[N-(4-cyanophenyl)amino]-2,6-dimethyl-3-nitropyridine 2,6-dimethyl-4-(4-fluorophenylamino)-3-nitropyridine 5,7-Dimethyl-pyrido[3,4-e][1,2,4]triazine

2,6-二甲基-4-羟基吡啶置于硫酸,三氧化硫,硝酸,三氯氧磷体系中,化学反应 82.0H,反应生成4-氯-2,6-二甲基-3-硝基吡啶
参考文献:Inhibitors Of Acyl-Coa:Cholesterol O-Acyltransferase. 3. Discovery Of A Novel Series Of N-Alkyl-N-[(Fluorophenoxy)Benzyl]-N'-Arylureas With Weak Toxicological Effects On Adrenal Glands
标题:Inhibitors Of Acyl-Coa:Cholesterol O-Acyltransferase. 3. Discovery Of A Novel Series Of N-Alkyl-N-[(Fluorophenoxy)Benzyl]-N'-Arylureas With Weak Toxicological Effects On Adrenal Glands
摘要:A Series Of N-Alkyl-N-[(Fluorophenoxy)Benzyl]-N'-Arylureas Were Prepared And Evaluated For Their Ability To Inhibit Intestinal Acyl-Coa:Cholesterol O-Acyltransferase And To Inhibit Accumulation Of Cholesteryl Esters In Macrophages In Vitro. In Vivo Hypocholesterolemic Activity Was Assessed In Cholesterol-Fed Rats By Oral Administration As A Dietary Admixture And/or By Gavage In A Peg400 Vehicle. Modification Of The Alkyl Substituent On The N'-Aryl Moiety And On The Urea Nitrogen Significantly Influenced Macrophage Assay In Vitro. Toxicological Study Revealed A Distinct Relationship Between Macrophage Assay And The Toxicity Observed In Adrenal Glands Of Rabbits Treated With Representatives Of This Series Of Compounds. Investigations Utilizing The Macrophage Assay As An Indicator For Adrenal Toxicity Led To The Identification Of Compounds 1G (Fr190809) And 1K (Fr186485,Or Fr195249 As Its Hydrochloride Salt) As Potent,Nonadrenotoxic,Orally Efficacious Acat Inhibitors Irrespective Of The Administration Method.
Doi:10.1021/jm980399Q

专利信息

专利号:US-5149814-A
优先权日:1987-09-30
标 题:Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds
发明人：COOPER KELVIN; FRAY MICHAEL J; RICHARDSON KENNETH; STEELE JOHN
权利人:PFIZER
摘要:Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R 3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.

专利号:US-5070205-A
优先权日:1987-09-30
标 题:Alkyl 2-benzylidene-4-(benzimidazol-1-yl) benzoylacetate esters as intermediates
发明人：COOPER MELVIN; FRAY MICHAEL J; RICHARDSON KENNETH; STEELE JOHN
权利人:PFIZER
摘要:Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R 3 is lower alkyl; Y is 1,4-phenylene and X is a benzimidazol-1-yl.