CAS: 1668-19-5; 3-(Dibenzo[b,E]Oxepin-11(6H)-Ylidene)-N,N-Dimethylpropan-1-Amine

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CAS号124-40-3 二甲胺 | CAS号22684-91-9 多塞平N-氧化物 | CAS号1229-29-4 盐酸多塞平 | CAS号22684-91-9 多塞平N-氧化物

合成工艺路线路线简述

    盐酸多塞平置于sodium Hydroxide体系中,用 水 用作溶剂,化学反应生成多虑平
    参考文献:Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
    标题:Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
    摘要:通过使用低剂量多塞平(例如1-6毫克),可以预防早醒,并提高睡眠效率,使睡眠周期中第7和第8小时的睡眠更好.

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    专利信息


    专利号:US-9040739-B2
    优先权日:2012-06-18
    标题 :Catalyst and method for synthesis of lactic acid and its derivatives
    发明人:ZHOU XIAOPING; BI RUI
    权利人:ZHOU XIAOPING; BI RUI; MICROVAST POWER SYSTEMS CO LTD
    摘要:A catalyst for synthesis of lactic acid and it derivatives is provided. The catalyst includes SnY2.mH 2 O and at least one of NH 4 X or quaternary ammonium salts, wherein X and Y are selected from F—, Cl—, Br—, I—, CH 3 SO 3 —, C 6 H 5 SO 3 —, CH 3 C 6 H 4 SO 3 — or CN—, m represents an integer of 1 to 15. A method for synthesis of lactic acid and it derivatives with the above catalyst is also provided. By using the above catalyst and method, it is capable of converting carbohydrate-containing raw material to lactic acid and its derivatives directly in a more efficient and economical way.

    专利号:US-10005720-B2
    优先权日:2013-04-05
    标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
    发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
    权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
    摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

    专利号:US-9422216-B2
    优先权日:2012-08-27
    标 题:Method for synthesis of lactic acid and its derivatives and catalyst for preparing same
    发明人:ZHOU XIAOPING
    权利人:MICROVAST POWER SYSTEMS CO LTD; MICROVAST POWER SYSTEMS CO LTD
    摘要:The present disclosure provides a catalyst for preparing lactic acid and derivatives thereof, comprising at least one of metallic compounds MX n , wherein M is selected from Na, K, Mg, Ca, Sr, Ba, Al, Ga, In, Sn, Sb, Bi, Cr, Mn, Fe, Co, Ni and Zn, and n is an integer of 1 to 6. The present disclosure further provides a method for synthesis of lactic acid and derivatives thereof, wherein at least one raw material including carbohydrates, at least one alcohol, at least one of the aforesaid catalysts and at least one solvent are heated to react to prepare lactic acid and derivatives thereof.

    专利号:US-11717498-B2
    优先权日:2013-12-31
    标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
    发明人:POPP KARL; MECKLER HAROLD
    权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
    摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

    专利号:US-7576211-B2
    优先权日:2004-09-30
    标题 :Synthesis of thienopyridinone compounds and related intermediates
    发明人:DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
    权利人:EPIX DELAWARE INC
    摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

    专利号:US-7101521-B2
    优先权日:2000-09-29
    标题 :Method for the preparation of cathode active material and method for the preparation of non-aqueous electrolyte
    发明人:HOSOYA MAMORU; TAKAHASHI KIMIO; FUKUSHIMA YUZURU
    权利人:SONY CORP
    摘要:A LiFePO 4 carbon composite material is to be synthesized in a single phase satisfactorily to prevent the deterioration of the performance of the cathode active material from occurring and achieve superior cell characteristics. In preparing a cathode active material, starting materials for synthesis of a compound represented by the general formula Li x FePO 4 , where 0
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    主要参考文献


    1: Matheson E, Hainer BL. Insomnia: Pharmacologic Therapy. Am Fam Physician. 2017 Jul 1;96(1):29-35. Review. doi: 10.4140/TCP.n.2017.156. Review. doi: 10.1016/j.smrv.2014.06.001. Epub 2014 Jun 19. Review. doi: 10.1200/JCO.2013.53.2630. Epub 2014 Apr 14.
    5: Laffleur F, Zilio M, Shuwisitkul D. Modified biomolecule as potential vehicle for buccal delivery of doxepin. Ther Deliv. 2016 Oct;7(10):683-689. doi: 10.1111/hdi.12455. Epub 2016 Jul 11. doi: 10.1097/YIC.0000000000000025.
    8: Shiroishi M, Kobayashi T. Structural Analysis of the Histamine H(1) Receptor. Handb Exp Pharmacol. 2017;241:21-30. doi: 10.1007/164_2016_10. Review. doi: 10.1016/j.jad.2017.11.046. Epub 2017 Nov 13. doi: 10.1016/j.ijpharm.2014.10.060. Epub 2014 Nov 1. doi: 10.1016/j.ejpb.2017.04.019. Epub 2017 Apr 21. doi: 10.1016/j.chroma.2016.11.003. Epub 2016 Nov 4. doi: 10.1002/ar.23677. Epub 2017 Aug 28. doi: 10.1093/sleep/zsx086. doi: 10.1002/jssc.201600673. Epub 2016 Nov 25. doi: 10.1186/s12871-015-0098-5.

    合成参考文献


    参考文献:10.1371/journal.pone.0021881
    摘要:Yang Z, Zhao J, Jiang Y, Li C, Wang J, Weng X, Northoff G. Altered Negative Unconscious Processing in Major Depressive Disorder: An Exploratory Neuropsychological Study. PLoS ONE. 2011 Jul 06;6(7):e21881. doi: 10.1371/journal.pone.0021881.
    参考文献:10.1186/1471-2377-5-22
    摘要:Baraniuk JN, Casado B, Maibach H, Clauw DJ, Pannell LK, Hess S S. A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. BMC Neurol. 2005 Dec 01;5():22.
    参考文献:10.4103/0019-5545.82567
    摘要:Ramachandraih CT, Subramanyam N, Bar KJ, Baker G, Yeragani VK. Antidepressants: From MAOIs to SSRIs and more. Indian J Psychiatry. 2011 Apr;53(2):180–2.
    参考文献:10.3389/fnsys.2011.00049
    摘要:Collins-Praino LE, Paul NE, Rychalsky KL, Hinman JR, Chrobak JJ, Senatus PB, Salamone JD. Pharmacological and physiological characterization of the tremulous jaw movement model of parkinsonian tremor: potential insights into the pathophysiology of tremor. Front Syst Neurosci. 2011;5():49.
    参考文献:10.3389/fphar.2011.00017
    摘要:Smith HS, Bracken D, Smith JM. Pharmacotherapy for fibromyalgia. Front Pharmacol. 2011;2():17.
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