专利号:US-9938297-B2 优先权日:2014-08-04 标 题:Process for the synthesis of everolimus and intermediates thereof 发明人:RAO DHARMARAJ RAMACHANDRA; MALHOTRA GEENA; PULLELA VENKATA SRINIVAS; ACHARYA VINOD PARAMESHWARAN 权利人:CIPLA LTD; CIPIA LTD 摘要:The present invention relates to a novel process for the synthesis of everolimus of formula (I): n nand intermediates thereof.
专利号:US-5286901-A 优先权日:1990-03-09 标题:Prescursors for and synthesis of mono- and difunctionalized acetylenes and difunctional 1,3-diynes 发明人:STANG PETER J; CRITTELL CHARLES M; WILLIAMSON BOBBY L; ZHDANKIN VIKTOR 权利人:UNIV UTAH RES FOUND 摘要:Precursors and methods for the synthesis of mono- and difunctionalized acetylenes are described. The invention includes novel tricoordinate iodonium transfer reagents and novel alkynyldi(phenyliodonium) salts, both of which are precursors for the functionalized acetylenes. The iodonium transfer reagents take the general form of mixed iodonium sulfonates PhI + (X)OSO 2 R f , where X may be OAc, NHAc, NCO, or CN. These mixed iodonium sulfonates are produced by reaction of iodosobenzene with certain substituted trimethylsilanes. n To make the alkynyldi(phenyliodonium) salt PhI + C.tbd.CI + Ph•2 R f SO 3 - ,a mixed iodonium sulfonate is reacted with a bistin acetylene of the kind R' 3 SnC.tbd.CSnR' 3 . Alternatively, the reaction may be performed with disubstituted tin diacetylenes to produce PhI + C.tbd.C-C.tbd.CI + Ph•2 R f SO 3 - to produce a dialkynyldi(phenyliodonium) salt. Subsequent reaction of a nucleophile with the alkynyldi(phenyl-iodonium) salt or dialkynyldi(phenyliodonium) salt produces a difunctional acetylene or a difunctional 1,3-diyne, respectively.
专利号:US-10421873-B2 优先权日:2015-05-25 标 题 :Method for in-site synthesis of transparent conductive coating of poly(3,4-ethylenedioxythiophene)/nano silver 发明人:LI JIANXIONG; MA YAXIAO; LIU ANHUA 权利人:UNIV SOUTH CHINA TECH 摘要:A method for in-site synthesis of transparent conductive coating of poly(3,4-ethylenedioxythiophene)/nano silver hybrid on transparent substrate is provided. Transparent substrate with oxidant coating containing silver salt is immersed into 3,4-ethylenedioxythiophene (EDOT) solution. The oxidant turns EDOT monomer to poly(3,4-ethylenedioxythiophene) (PEDOT) coating on the transparent substrate; meanwhile, the silver salt itself is reduced to nano silver by the EDOT monomer, resulting in a nano silver-doped PEDOT coating. Thereby, a transparent conductive film made of PEDOT/nano silver coating on transparent substrate is obtained. The transparent conductive film with PEDOT/nano silver coating prepared in the present invention possesses the advantages of high electrical conductivity, optical transparency and environmental stability.
专利号:US-2016317682-A1 优先权日:2015-04-30 标题:PREPARATION OF Ag18F AND ITS USE IN THE SYNTHESIS OF PET RADIOTRACERS 发明人:SCOTT PETER J H; BROOKS ALLEN F; ICHIISHI NAOKO; SANFORD MELANIE S 权利人:UNIV MICHIGAN REGENTS; THE REGENTS OFTHE UNIV OF MICHIGAN 摘要:Copper-catalyzed radiofluorination of aryl iodides using Ag 18 F, methods of preparing Ag 18 F, and compounds obtained by copper-catalyzed radiofluorination of aryl iodides using Ag 18 F are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.
专利号:US-9822053-B2 优先权日:2016-01-28 标题:Single step conversion of N-butyraldehyde to 2-ethylhexanal 发明人:BOPPANA Venkata Bharat; HAMPTON JR KENNETH WAYNE; LIU ZHUFANG; SUMNER JR CHARLES EDWAN; TUSTIN GERALD C; STEINMETZ GUY RALPH; STEFFEY MELISSA PAGE 权利人:EASTMAN CHEM CO 摘要:Disclosed is a method of making and using a titania supported palladium catalyst for the single step synthesis of 2-ethylhexanal from a feed of n-butyraldehyde. This titania supported palladium catalyst demonstrates high n-butyraldehyde conversion but also produces 2-ethylhexanal in an appreciable yield with maintained activity between runs. This method provides a single step synthesis of 2-ethylhexanal from n-butyraldehyde with a catalyst that can be regenerated that provides cleaner downstream separations relative to the traditional caustic route.
专利号:US-2012301720-A1 优先权日:2009-11-16 标题 :Metal island coatings and method for synthesis 发明人:KOBAN WIELAND; PEUKERT WOLFGANG; KLUPP TAYLOR ROBIN; DISTASO MONICA; BAO HUIXIN; VASYLYEV SERHIY 权利人:KOBAN WIELAND; PEUKERT WOLFGANG; KLUPP TAYLOR ROBIN; DISTASO MONICA; BAO HUIXIN; VASYLYEV SERHIY; BASF SE 摘要:The present invention relates to methods for synthesis of metallic island coatings with tunable island coverage and morphology on a variety of substrates. Particularly, the present invention relates to substrates coated with one or more metal islands and the use of said island-coated substrates.
摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 77. 摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 21. 摘要:Campbell, M. J.; Toste, F. D., Science of Synthesis Knowledge Updates, (2012) 1, 135. 摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 26. 摘要:Campbell, M. J.; Toste, F. D., Science of Synthesis Knowledge Updates, (2012) 1, 152.