CAS: 252049-10-8; Fmoc-Lys(Me2)-Oh.Hcl

相似化合物

951695-85-5 2044709-77-3 201004-29-7

聚合甲醛,Fmoc-L-赖氨酸盐酸盐置于sodium Tetrahydroborate,溶剂黄146体系中,用 1,4-二氧六环 用作溶剂,化学反应 1.0H,以100%的收率获得fmoc-N',N'-二甲基-L-赖氨酸盐酸盐
参考文献:通过用不同的钯配合物进行化学选择性脱保护来化学合成半胱氨酸.
标题:通过用不同的钯配合物进行化学选择性脱保护来化学合成半胱氨酸.
摘要:我们报告使用不同的钯配合物,以促进有效的化学蛋白质合成选择性去除n末端和内部cys保护基团.利用正交脱保护对,我们通过pd(0)介导的alloc脱保护用于一锅多肽连接和pd(II)cl 2介导的acm脱保护的结合,完成了包含三甲基化lys的组蛋白h3的化学合成,以恢复天然cys脱硫后的残留物.
Doi:10.1021/acs.Orglett.9B03152

专利信息

专利号:US-2025170267-A1
优先权日:2022-02-28
标 题 :Antibody-drug conjugate precursor and intermediate for synthesis thereof
发明人：TSUZAKI YASUNORI; MIZUNO GEN; KASHIWAGI TAKAMASA; TANAKA MASAYUKI; SHIMIZU HAYATO; NONOUCHI SHIMPEI; MATSUSHITA TAKASHI; KIMURA TOMIO
权利人:UBE CORP
摘要:A method for improving the stability of an antibody-drug conjugate in a living body, and a conjugate precursor for producing a stabilized antibody-drug conjugate. An antibody-drug conjugate precursor represented by the following general formula (I) or a salt thereof, a synthetic intermediate thereof or a salt thereof, n Z-L-D  (I)n n where Z is a reactive group which can react with a functional group present in an antibody or a modified antibody; D is an antitumor drug residue in which one hydrogen atom or one hydroxy group is removed from any position of an antitumor drug molecule or an analog thereof or a derivative thereof; L is a linker which links Z to D; and at least any one of D and L has one or more lactonyl group(s) at any position(s) as substituent(s) or protecting group(s).