CAS: 320-98-9; 5-Fluoro-2-Nitrobenzoic Acid

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CAS号455-38-9 间氟苯甲酸 | CAS号446-33-3 5-氟-2-硝基甲苯 | CAS号611-05-2 3-甲基-4-硝基苯胺 | CAS号352-70-5 3-氟甲苯 | CAS号319-24-4 2-氨基-5-氟苯甲酸甲酯 | CAS号393-85-1 5-氟-2-硝基苯甲酸甲酯 | CAS号395-81-3 5-氟-2-硝基苯甲醛 | CAS号446-08-2 2-氨基-5-氟苯甲酸 | CAS号287121-32-8 (5-氟-2-硝基苯基)甲醇 | CAS号603306-52-1 5-氟-1H-吲哚-7-甲醛 | CAS号63069-49-8 2-氨基-5-氟苯甲酰胺 | CAS号364-51-2 5-氟-2-硝基苯甲酸乙酯 | CAS号3416-05-5 2',3'-二脱氧胸苷 | CAS号13280-60-9 5-氨基-2-硝基苯甲酸

间氟苯甲酸置于硫酸,硝酸体系中,化学反应 1.0H,以93%的收率获得产物5-氟-2-硝基苯甲酸
参考文献:2-((3,5-二硝基苯甲基)硫代)喹唑啉酮:由脱氮黄素 (F420) 依赖性硝基还原酶 (Ddn) 激活的有效抗分枝杆菌药物
标题:2-((3,5-二硝基苯甲基)硫代)喹唑啉酮:由脱氮黄素 (F420) 依赖性硝基还原酶 (Ddn) 激活的有效抗分枝杆菌药物
摘要:交换先前合成但尚未公开的 5-Cyano-4-(Methylthio)-2-Arylpyrimidin-6-Ones 4 的 2 和4位取代基,闭环和进一步优化导致鉴定出有效的抗结核药物 2-硫代喹唑啉酮26.结构-活性关系(sar)研究表明,两个间硝基取代基在抗结核活性中发挥着至关重要的作用,而在喹唑啉酮核心上引入极性取代基可以减少牛血清白蛋白(bsa)的结合(63C,63D).虽然大多数测试的喹唑啉酮类化合物没有表现出针对 Mrc-5 的细胞毒性,但通过 Ames 测试发现最有效的化合物26具有诱变性.该类似物对结核分枝杆菌胸苷酸激酶(3-氰基吡啶酮的靶标,位于当前类似物的基础上)表现出中等的抑制效力,表明本发明的s-取代的硫代喹唑啉酮的全细胞抗分枝杆菌活性可能是由于调节替代或额外目标.观测到受辅因子 F 420生物合成 (Fbic),辅因子还原 (Fgd) 或去氮黄素依赖性硝基还原酶活性
DOI:10.1021/acs.Jmedchem.0C01374

专利信息

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-9732112-B2
优先权日:2010-05-28
标 题:Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization
发明人：MA ZHAOCHUN; MULLAH KHAIRUZZAMAN BASHAR; EASON ROBERT G
权利人:LIFE TECHNOLOGIES CORP
摘要:Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.

专利号:US-8658776-B2
优先权日:2010-05-28
标题:Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization

专利号:US-2011294122-A1
优先权日:2010-05-28
标 题:Synthesis of 2', 3'-Dideoxynucleosides for Automated DNA Synthesis and Pyrophosphorolysis Activated Polymerization

专利号:US-2015045547-A1
优先权日:2010-05-28
标题 :Synthesis Of 2' , 3' -Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization

专利号:WO-2011150277-A2
优先权日:2010-05-28
标题 :Synthesis of 2', 3'-dideoxynucleosides for automated dna synthesis and pyrophosphorolysis activated polymerization