CAS: 3486-67-7; Dibenzo[a,G]Quinolizinium, 5,6-Dihydro-2,3,9,10-Tetramethoxy-

该化合物是一种天然的碱性碱,属于类化合物,称为异丙醇藻类,主要来源于各种植物来源,包括棕榈树树的树皮和柏贝里达塞亚氏家族的其他物种;棕榈树的特征是黄色晶体外观,具有反映其复杂结构的分子配方;该化合物展示了一系列生物活动,包括抗微生物,抗炎和潜在的抗癌特性,这使药理学研究感兴趣;棕榈树在传统医学中的作用也众所周知,特别是在用于治疗作用的某些文化中,其溶性在不同溶剂中各不相同,而且可以发生各种化学反应,包括氧化和减少,这与其在有机合成和药用化学中的应用有关;

结构式图片

上下游产品

CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号86-51-1 2,3-二甲氧基苯甲醛 | CAS号16176-68-4 巴马亭红碱

合成工艺路线路线简述

    7,8-Dihydro-8-Hydroxypalmatine置于sodium Hydroxide体系中,用 乙醇,氯仿,水 作为反应溶剂,化学反应 4.0H,以20%的收率获得产物黄藤素
    参考文献:A 7,8-Dihydro-8-Hydroxypalmatine From Enantia Chlorantha
    标题:A 7,8-Dihydro-8-Hydroxypalmatine From Enantia Chlorantha
    摘要:7,8-Dihydro-8-Hydroxypalmatine,A Novel Protoberberine Type Alkaloid,Along With Palmatine,Has Been Isolated And Characterized From An Anti-Hiv Active Extract From Enantia Chlorantha. The Structures Of The Two Compounds Were Elucidated By Spectroscopic Analyses And From Chemical Evidence. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
    DOI:10.1016/s0031-9422(98)00382-3

    海关参考信息

    专利信息


    专利号:WO-2025031833-A1
    优先权日:2023-08-04
    标 题:Recombinant strain and use thereof in production of scoulerine
    发明人:CHEN YUN; JIAO XIANG
    权利人:CHRYSEA LTD; CHEN YUN
    摘要:Disclosed are recombinant yeast strains and a use thereof in the production of a benzylisoquinoline alkaloid. The recombinant yeast strains comprise berberine bridge enzyme. De novo synthesis of scoulerine and a benzylisoquinoline alkaloid is achieved through multiple strategies, and the yield thereof is significantly increased. The recombinant yeast strains provided by the present invention can produce scoulerine and other benzylisoquinoline alkaloids at high efficiency, and has important value in applications.

    专利号:US-8759480-B2
    优先权日:2006-02-17
    标题:Contoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides
    发明人:ROBINSON ANDREA; ELARIDI JOMANA
    权利人:ROBINSON ANDREA; ELARIDI JOMANA; SYNGENE LTD
    摘要:According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.

    专利号:WO-2024121871-A1
    优先权日:2022-12-09
    标 题 :Genetic modification of microbes for production of nitrogen and carbon-containing compounds
    发明人:KANUMURU RAHUL RAJU
    权利人:FERTIS INDIA PVT LTD
    摘要:The present invention relates to a novel method for sustainable in vitro and in vivo production of nitrogen and carbon containing compounds such as and not limited to Proteins, Enzymes, peptides amino acids, nucleotides, vitamins, etc. The present invention relates to a novel method that includes gene modifications in microbes, more specifically involving gene modifications resulting in nitrogen fixation and/or ammonia fixation or increased nitrogen fixation and/or ammonia fixation or carbon fixation/increased carbon fixation or Hydrogen fixation/increased Hydrogen fixation with increased synthesis/ regeneration of anyone or all compounds including ATP, NADH, NADPH, Pyruvate and Acetyl CoA with or without utilisation/reduction enhanced utilisation/reduction of Nitrate, Nitrite, N2O, N2O2 and/or carbon containing substrates

    专利号:US-2009227470-A1
    优先权日:2005-12-21
    标题:Selection of biocatalysts for chemical synthesis
    发明人:WITHOLT BERNARD; VAN BEILEN JAN BERTHOLD; VAN SINT FIET STEPHAN JOHANNES
    权利人:WITHOLT BERNARD; VAN BEILEN JAN BERTHOLD; VAN SINT FIET STEPHAN JOHANNES
    摘要:The present invention relates to a method of detecting among a population of candidate biocatalysts a biocatalyst capable of catalyzing a chemical conversion reaction from a substrate to a product, said method comprising the steps of: a) providing a host cell comprising:—at least one product-inducible expression system comprising nucleic acid encoding at least one detector gene operably linked to a regulatory element, wherein the expression of said detector gene is inducible by said product, and—at least one biocatalyst expression system comprising nucleic acid encoding at least one candidate biocatalyst, wherein said at least one candidate biocatalyst is selected from said population of candidate biocatalysts, b) contacting said host cell with said substrate under conditions wherein said nucleic acid encoding at least one candidate biocatalyst is expressed in said host cell and wherein said substrate is allowed to contact said candidate biocatalyst, and wherein said substrate is converted into said product in case said candidate biocatalyst is capable of catalyzing said reaction, and c) detecting said host cell as one comprising a biocatalyst capable of catalyzing said chemical conversion reaction on the basis of the expression of said detector gene.

    专利号:US-2013123463-A1
    优先权日:2006-02-17
    标题:Methods for the synthesis of two or more dicarba bridges in organic compounds

    专利号:US-2012142892-A1
    优先权日:2006-02-17
    标题:Contoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides
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    主要参考文献


    1: Long J, Song J, Zhong L, Liao Y, Liu L, Li X. Palmatine: A review of its pharmacology, toxicity and pharmacokinetics. Biochimie. 2019 Jul;162:176-184. doi: 10.1016/j.biochi.2019.04.008. Epub 2019 Apr 30.
    105:76-85. doi: 10.1016/j.molimm.2018.10.015. Epub 2018 Nov 27.
    14:4963-4974. doi: 10.2147/DDDT.S280520.

    合成参考文献


    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 335.
    参考文献:10.1093/chromsci/42.4.207
    摘要:Dai R, Li K, Li Q, Bi K. Determination of Mangiferin, Jateorrhizine, Palmatine, Berberine, Cinnamic Acid, and Cinnamaldehyde in the Traditional Chinese Medicinal Preparation Zi-Shen Pill by High-Performance Liquid Chromatography. Journal of Chromatographic Science. 2004 Apr 01;42(4):207–10. doi: 10.1093/chromsci/42.4.207.
    参考文献:10.1021/tx050356u
    摘要:Inbaraj JJ, Kukielczak BM, Bilski P, He YY, Sik RH, Chignell CF. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine. Chem Res Toxicol. 2006 Jun;19(6):739–44. doi: 10.1021/tx050356u.
    参考文献:10.1016/j.saa.2015.09.038
    摘要:Wang Y, Hu Y, Wu T, Zhang L, Liu H, Zhou X, Shao Y. Recognition of DNA abasic site nanocavity by fluorophore-switched probe: Suitable for all sequence environments. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2016 Jan;153():645–50. doi: 10.1016/j.saa.2015.09.038.
    参考文献:10.1016/j.bbrc.2017.01.159
    摘要:Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochemical and Biophysical Research Communications. 2017 Mar;484(3):636–41. doi: 10.1016/j.bbrc.2017.01.159.
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