CAS: 4316-94-3; 6-Chloro-5-Nitropyrimidin-4-Amine

相似化合物

4316-98-7 31221-68-8 23126-82-1

上下游产品

CAS号4316-93-2 4,6-二氯-5-硝基嘧啶 | CAS号186581-53-3 重氮甲烷 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1193-24-4 4,6-二羟基嘧啶 | CAS号4316-98-7 6-氯嘧啶-4,5-二胺 | CAS号24957-88-8 4-Pyrimidinamin... | CAS号245450-04-8 1-B°C-4-(6-氨基-5... | CAS号2846-89-1 4,5-二氨基-6-巯基嘧啶 | CAS号6311-26-8 N,N-dimethyl-5-... | CAS号40816-36-2 5-nitro-N-pheny... | CAS号4094-00-2 N-methyl-5-nitr... | CAS号55740-63-1 8-Methyl-10H-py... | CAS号56153-74-3 2-(5,6-diaminop... | CAS号63931-16-8 10H-Pyrido[2,3-...

4,6-二氯-5-硝基嘧啶置于氨,碳酸氢钠体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.0H,反应生成 4-氨基-5-硝基-6-氯嘧啶
参考文献:通过5-氨基-4-氯-6-烷基氨基嘧啶与n,N-二甲基链烷酰胺和醇盐离子的反应有效地一锅合成6-烷氧基-8,9-二烷基嘌呤
标题:通过5-氨基-4-氯-6-烷基氨基嘧啶与n,N-二甲基链烷酰胺和醇盐离子的反应有效地一锅合成6-烷氧基-8,9-二烷基嘌呤
摘要:许多新的6-烷氧基-8,9-(二取代)嘌呤的合成是通过将相应的中间体5-氨基-4-氯-6-(烷基氨基)嘧啶经醇盐和各种n促进的环化来完成的,N-二甲基酰胺,后者用作溶剂-试剂.通过这种三组分缩合反应,我们能够在嘌呤环的8位引入烷基,同时用烷氧基部分亲核取代6-氯.
DOI:10.1016/s0040-4020(02)00867-0

专利信息

专利号:US-3948883-A
优先权日:1974-11-11
标题:Synthesis of purine nucleosides
发明人：RANGANATHAN RAMACHANDRAN S
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:A desired purine-containing nucleoside is synthesized by condensing a nitropyrimidine with a thionoxazolidine that is an adduct of a sugar unit and an oxazolidine ring unit having two adjacent carbon atoms in common. Prior to condensing the thionoxazolidine is converted to the bromo-mercuric derivative to promote the reaction at the nitrogen site. The N-alkylated condensation product is reduced to produce an amino-pyrimidine nucleoside which is then heated under conditions to cyclize it to a mercapto-purine nucleoside. The cyclized product is finally desulfurized to produce the desired purine-containing nucleoside. The compounds are useful as anti-viral agents.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:CN-86102542-A
优先权日:1986-10-20
标题 :Synthesis of Sugar-N-(aminopyrimidinyl)-oxazolidine-2-thione

专利号:CN-1021736-C
优先权日:1986-10-20
标题 :Synthesis method of glucoiso-N-(aminopyrimidinyl)-oxazolidine-2-thione