CAS: 70775-75-6; 1,1'-(Decane-1,10-Diyl)Bis(N-Octylpyridin-4(1H)-Imine) Dihydrochloride

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1,10-dichlorodecane 4-(°Ctylamino)pyridine n-°Ctylamine hydr°Chloride 4-aminopyridine

4-氨基吡啶 在 乙醇,三乙酰氧基硼氢化钠体系中,用 乙酸丁酯作为反应溶剂,反应 45.0H,获得 octenidine DihydroChloride
参考文献:一种奥替尼啶碱的制备方法
标题:一种奥替尼啶碱的制备方法
摘要:本发明属于医药合成技术领域,具体涉及一种奥替尼啶碱的制备方法.本发明提供了一种奥替尼啶碱的制备方法,包括以下步骤:将4‑氨基吡啶,辛醛,还原剂和第一有机溶剂混合,进行还原胺化反应,得到n‑辛基吡啶‑4‑胺;将所述n‑辛基吡啶‑4‑胺,1,10‑二卤代癸烷,碱性溶剂和第二有机溶剂混合,进行烷基化反应,得到奥替尼啶二氢卤酸盐;将所述奥替尼啶二氢卤酸盐,无机碱溶解于第三有机溶剂,进行去质子化反应,得到奥替尼啶碱.本发明提供的制备方法仅需要进行简单的化学反应即可制备得到奥替尼啶碱,操作简单,易于工业化生产.

专利信息

专利号:WO-2021013997-A1
优先权日:2019-07-25
标 题:Process for the synthesis of n-alkyl-4-pyridinamines

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:EP-4003957-B1
优先权日:2019-07-25
标 题 :Process for the synthesis of n-alkyl-4-pyridinamines
发明人：CONTRERAS LASCORZ JUAN; DURÃ?N LÓPEZ ERNESTO
权利人:MEDICHEM SA

专利号:EP-4003957-A1
优先权日:2019-07-25
标 题 :Process for the synthesis of n-alkyl-4-pyridinamines

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.