专利号:US-2024287126-A1 优先权日:2021-05-14 标 题:Novel synthesis of cholesterol 发明人:SCHINZER DIETER; SPIESS OLIVER; MUNT MAXIM; INDOLESE ADRIANO; ROUX LIONEL 权利人:CORDENPHARMA INT GMBH; UNIV OTTO VON GUERICKE MAGDEBURG; CORDENPHARMA INT 摘要:The invention relates to a synthesis of cholesterol; a ring opening step of the compound of formula (I) and subsequent activation and reduction step yielding cholesterol. The inventions relates also to intermediates achieved during said synthesis.
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-8481501-B2 优先权日:2004-05-28 标 题 :Synthesis of metabolically stable analgesics, pain medications and other agents 发明人:CASHMAN JOHN R; MACDOUGALL JAMES M 权利人:CASHMAN JOHN R; MACDOUGALL JAMES M; HUMAN BIOMOLECULAR RES INST 摘要:Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.
专利号:US-4002664-A 优先权日:1973-06-09 标题 :Manufacture of dimethylaminobenzenecarboxylic acid esters 发明人:QUADBECK-SEEGER HANS-JUERGEN; HOCH HELMUT 权利人:BASF AG 摘要:Dimethylaminobenzenecarboxylic acid esters are produced by reaction of nitrobenzenecarboxylic acid esters with formaldehyde and hydrogen under pressure in the presence of a hydrogenation catalyst containing metals of atomic numbers 24 to 29 and of a weak acid, at temperatures from 35° to 150° C. The products are starting materials for the synthesis of dyes, especially of crystal violets, and of reactive dyes and pesticides.
专利号:US-4133828-A 优先权日:1975-08-28 标题:Manufacture of dimethylaminobenzenesulfonates 发明人:SCHEUERMANN HORST; HOCH HELMUT 权利人:BASF AG 摘要:Dimethylaminobenzenesulfonates are manufactured by reacting nitrobenzenesulfonates with formaldehyde and hydrogen in the presence of a hydrogenation catalyst containing a metal of atomic number from 24 to 29 and of phosphoric acid and water at a pH of from 2 to 3.5, at from 50 to 150° C, under a pressure of at least 40 bars, with a residence time of from 1 to 15 minutes. The products are starting materials for the synthesis of dyes, especially of rhodamine dyes, oxazine dyes and reactive dyes, and also of pharmaceuticals and pesticides.
专利号:US-7838053-B2 优先权日:2004-03-11 标题:Barley for production of flavor-stable beverage 发明人:BREDDAM KLAUS; OLSEN OLE; SKADHAUGE BIRGITTE; LOK FINN; KNUDSEN SOEREN; BECH LENE MOELSKOV 权利人:CARLSBERG AS 摘要:According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which-through further enzymatic or spontaneous reactions-may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off flavors, even after prolonged storage of the beverage.
[参考文献]: G E Anthon, Et Al. Colorimetric Method For The Determination Of Lipoxygenase Activity. J Agric Food Chem. 2001 Jan;49(1):32-7. [参考文献]: M P Castillo, Et Al. Determination Of Manganese Peroxidase Activity With 3-Methyl-2-Benzothiazolinone Hydrazone And 3-(Dimethylamino)Benzoic Acid. Anal Biochem. 1994 May 1;218(2):399-404. [参考文献]: Mikako Ogawa, Et Al. Synthesis And Evaluation Of New Imaging Agent For Central Nicotinic Acetylcholine Receptor α7 Subtype. Nucl Med Biol. 2010 Apr;37(3):347-55. [参考文献]: T T Ngo, Et Al. A Sensitive And Versatile Chromogenic Assay For Peroxidase And Peroxidase-Coupled Reactions. Anal Biochem. 1980 Jul 1;105(2):389-97.
合成参考文献
参考文献:10.1186/1475-2859-9-10 摘要:Zanaroli G, Di Toro S, Todaro D, Varese GC, Bertolotto A, Fava F. Characterization of two diesel fuel degrading microbial consortia enriched from a non acclimated, complex source of microorganisms. Microbial Cell Factories. 2010 Feb 16;9(1):10. doi: 10.1186/1475-2859-9-10.