CAS: 124-76-5; Rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]Heptan-2-Ol

该化合物是一种双环有机化合物,被归类为单细胞,分子式为C10H18O.在室温下,它是一种无色的黄色固体,在浅色的黄色,具有典型的阵营般的气味.Isoborneol是甲状腺的立体异构体,在原子的排列上有所不同,有助于其独特的特性.它在乙醇和乙醇等有机溶剂中溶解,但在水中溶解有限.Isoborneol经常用于香气工业,因为它的气味很好,并且也用于各种有机化合物的合成.此外,它还在传统医学中应用,并且作为一种潜在的昆虫驱虫剂.该化合物可以通过减少阵营或其他合成方法获得.Isoborneol展示了两种抗生素特性,其中两种对活生物活动不同.其安全简介表明,它应该谨慎处理,因为接触皮肤或眼睛可能会引起刺激.

结构式图片

相似化合物

76-49-3 464-48-2 464-49-3

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REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号464-49-3 D(+)-樟脑 | CAS号130979-66-7 (1R,2S,4R)-2-et... | CAS号64-17-5 乙醇 | CAS号28974-17-6 (1R)-2-exo-acet... | CAS号565-00-4 莰烯 | CAS号76-22-2 (±)-樟脑(合成) | CAS号6627-72-1 龙脑 | CAS号24393-70-2 2-methylisoborneol | CAS号464-43-7 右莰醇 | CAS号555-31-7 异丙醇铝 | CAS号76-22-2 (±)-樟脑(合成) | CAS号464-49-3 D(+)-樟脑

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-10751419-B2
    优先权日:2014-05-01
    标题:Method for synthesis of reactive conjugate clusters
    发明人:MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
    权利人:IONIS PHARMACEUTICALS INC
    摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

    专利号:US-12146136-B2
    优先权日:2020-03-26
    标题:Synthesis of modified oligonucleotides with increased stability
    发明人:KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
    权利人:UNIV MASSACHUSETTS
    摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

    专利号:US-3978084-A
    优先权日:1973-12-03
    标题 :Synthesis of biotin
    发明人:CONFALONE PASQUALE NICHOLAS; USKOKOVIC MILAN RADOJE; PIZZOLATO GIACOMO
    权利人:HOFFMANN LA ROCHE
    摘要:Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and thiophene intermediates in this synthesis.

    专利号:US-3979396-A
    优先权日:1973-12-03
    标 题 :Synthesis of biotin
    发明人:CONFALONE PASQUALE NICHOLAS; USKOKOVIC MILAN RADOJE; PIZZOLATO GIACOMO
    权利人:HOFFMANN LA ROCHE
    摘要:Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and dihydrothiophene intermediates in this synthesis.

    专利号:US-4029647-A
    优先权日:1973-12-03
    标 题 :Synthesis of biotin
    发明人:CONFALONE PASQUALE NICHOLAS; USKOKOVIC MILAN RADOJE; PIZZOLATO GIACOMO
    权利人:HOFFMANN LA ROCHE
    摘要:Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and thiophene intermediates in this synthesis.

    专利号:WO-2024260325-A1
    优先权日:2023-06-19
    标题 :Synthesis of macrocyclic compound and medical use of macrocyclic compound
    发明人:LU HONGFU; DING XIAO; REN FENG
    权利人:INSILICO MEDICINE IP LTD
    摘要:Provided in the present invention are the synthesis of a macrocyclic compound and the medical use of the macrocyclic compound. Specifically, provided in the present invention are a compound as show in formula (II), a stereoisomer thereof or a pharmaceutically acceptable salt thereof, which can be used as a CDK7 inhibitor.
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    主要参考文献


    1: Yuan X, Fei F, Sun H, Xiao C, Zhao X, Zhang Y, Zheng X. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. Int J Nanomedicine. 2018 Apr 12;13:2265-2274. doi: 10.2147/IJN.S159789. eCollection 2018.
    2: Song H, Wei M, Zhang N, Li H, Tan X, Zhang Y, Zheng W. Enhanced permeability of blood-brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle. Int J Nanomedicine. 2018 Mar 28;13:1869-1879. doi: 10.2147/IJN.S161237. eCollection 2018.
    3: Liao W, Huang X, Yin Y, Liu B, Zhu R. In vivo microdialysis with ultra performance liquid chromatography-mass spectrometry for analysis of tetramethylpyrazine and its interaction with borneol in rat brain and blood. Biomed Chromatogr. 2018 Jun;32(6):e4210. doi: 10.1002/bmc.4210. Epub 2018 Mar 2. doi: 10.1016/j.jfda.2016.10.012. Epub 2016 Dec 1. pii: E26. doi: 10.3390/toxins10010026.

    合成参考文献


    参考文献:10.1016/s0040-4020(01)00451-3
    摘要:Wise ML, Pyun H, Helms G, Assink B, Coates RM, Croteau RB. Stereochemical disposition of the geminal dimethyl groups in the enzymatic cyclization of geranyl diphosphate to (+)-bornyl diphosphate by recombinant (+)-bornyl diphosphate synthase from Salvia officinalis. Tetrahedron. 2001 Jun;57(25):5327–34. doi: 10.1016/s0040-4020(01)00451-3.
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