CAS: 13515-93-0; Methyl N-Methylglycinate Hydrochloride

该化合物是一种多用途有机化合物,主要用作制药和化学合成的中间体;盐盐的形态增强稳定性和溶性,使之适合受控反应;该化合物的特征是反应性酯类和二人基,能够用于化结合和其他功能化过程;其定义明确的结构确保合成应用的一贯性,特别是在开发活性药物成分(API)方面;盐酸盐的形态也有利于净化和处理;该化合物在生产高纯度衍生物,促进研究和工业环境中高效和可缩放的合成途径方面,具有可靠性,具有价值.

结构式图片

相似化合物

1212-53-9 31954-27-5 53386-64-4

物理性质

MSDS等安全信息

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

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CAS号42492-57-9 N-B°C-N-甲基甘氨酸甲酯 | CAS号67-56-1 甲醇 | CAS号107-97-1 肌氨酸 | CAS号74-88-4 碘甲烷 | CAS号238090-53-4 2-(methylamino)... | CAS号37619-24-2 1-甲基吡咯-2-羧酸甲酯 | CAS号42492-57-9 N-B°C-N-甲基甘氨酸甲酯 | CAS号1801-62-3 1,3-二甲基-2-硫代乙内酰脲 | CAS号72065-23-7 N-丙烯酰肌胺酸甲酯 | CAS号3415-35-8 4-甲基-3,4-二氢-1h-... | CAS号17289-20-2 1-甲基咪唑-5-甲酸甲酯 | CAS号40637-81-8 1-Methyl-1H-imi... | CAS号37115-47-2 2-(Methylamino)... | CAS号7801-91-4 N-苄氧羰基甘氨酰肌氨酸 | CAS号6596-81-2 1,3-二甲基-1H-咪唑-2...

合成工艺路线路线简述

    肌氨酸置于氯化亚砜体系中,用 甲醇 用作溶剂,化学反应生成肌氨酸甲酯盐酸盐
    参考文献:Method For Using Substrate In Peptide Syntheses
    标题:Method For Using Substrate In Peptide Syntheses
    摘要:基板包括一种多孔聚合物材料,其孔隙度至少为75%,孔径范围为1到100μm,并由多个孔相互连接,并且包含一种凝胶或适用于形成凝胶的材料,该凝胶或预凝胶材料被包含并保留在聚合物材料的孔内,并适用于与反应性物种相互作用.可通过在多孔聚合物材料的孔内沉积和保留凝胶或适用于形成凝胶的材料来制备.多孔聚合物材料的高孔隙度与凝胶在孔内的保留相结合,可实现高负载能力,特别是在肽合成领域.该基板可用于化学合成,色谱技术,离子交换和分离技术.

    海关参考信息

    专利信息


    专利号:EP-0150883-B1
    优先权日:1984-02-02
    标题 :Process for preparing n-(dibenzyloxyphosphoryl)-cyanamide and processes using said compounds as intermediate for the synthesis of phosphagen substances
    摘要:The invention relates to a process for preparing compounds of general formula: wherein R = Hydrogen, halogen, alkyl, nitro-group; said compounds, which are indicated hereinunder with the general term <> are useful as intermediates in the synthesis of phosphagen compounds such as phosphocreatine, phosphocreatinine and similar compounds. Such process is characterized in that dibenzyloxyphosphoryl chloride is reacted with cyanamide, N-(dibenzyloxyphosphoryl)-cyanamide being produced; this latter can react with substances provided with a primary or secondary amine function, to give the corresponding guanidinoderivatives; e.g., with a sarcosine derivative to give N-(dibenzyloxyphosphoryl)-creatine or N-(dibenzyloxyphosphoryl)-creatinine.

    专利号:US-2024425461-A1
    优先权日:2023-06-13
    标题 :Preparation process of intermediate, synthesis process of amino imidazole carboxylate ester and hplc purity measure method
    发明人：DUAN JIANXIN; LU ZHAOQIANG; FAN JINWEI; HUANG QUNHUI; ZHANG YANJUN; CHEN WEISU; QIN WEI
    权利人:ASCENTAWITS PHARMACEUTICALS LTD
    摘要:This invention relates to a process for preparing an intermediate of aminoimidazole carboxylate, a process for synthesizing aminoimidazole carboxylate and an HPLC method for determining purity. The process of preparing the intermediate of aminoimidazole carboxylate comprises subjecting a compound of formula I-2 and a formate as the reactants to a first-step reaction in a benzene solvent and at a temperature of −5° C.−5° C., with the addition of a solution of sodium alkoxide in such a way that the temperature of the reaction solution is not higher than 5° C., to obtain the intermediate of aminoimidazole carboxylate or a mixture comprising a compound of formula I-3, i.e., the intermediate of aminoimidazole carboxylate. By using a sodium alkoxide reagent, as a comparatively safe alternative to NaH and potassium tert-butoxide which are prone to cause fire hazards or explosions and are not suitable for use in large-scale production, the process of the present application can ensure smooth progression of the reaction to the product and effectively improve the overall safety of the reaction without noticeably impairing the reaction efficiency.

    专利号:US-12180228-B2
    优先权日:2019-06-05
    标题:Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
    发明人：MOVASSAGHI MOHAMMAD; OLSSON CHASE ROBERT; SCOTT TONY Z; CHEAH JAIME; PAYETTE JOSHUA NATHANIEL
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

    专利号:US-4560752-A
    优先权日:1984-03-02
    标题:Phosphinates or phosphonates useful for control of weeds
    发明人：LEE SHY-FUH
    权利人:ZOECON CORP
    摘要:Novel 5-(substituted amino)phenoxyalkyl-, phenylthioalkyl-, phenylsulfinylalkyl-, and phenylsulfonylalkylphosphinates and phosphonates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.

    专利号:EP-0150883-A2
    优先权日:1984-02-02
    标题:Process for preparing N-(dibenzyloxyphosphoryl)-cyanamide and processes using said compounds as intermediate for the synthesis of phosphagen substances

    专利号:US-5066784-A
    优先权日:1987-04-24
    标 题 :Method for using substrate in peptide syntheses
    发明人：SHERRINGTON DAVID C; SMALL PHILIP W
    权利人:UNILEVER PATENT HOLDINGS
    摘要:A substrate comprises a porous polymeric material having a porosity of at least 75% and comprising pores having a diameter within the range 1 to 100 μm and being interconnected by a plurality of holes, and a gel or material adapted in use to form a gel which gel or pre-gel materials is contained and retained within the pores of the polymeric material and is adapted in use to interact with a reactive species and can be made by depositing and retaining the gel or a material adapted in use to form the gel within the pores of the porous polymeric material. The high porosity of the porous polymeric material in combination with the retention of the gel within the pores permit high loading capacities, particularly in the area of peptide synthesis to be achieved. The substrate can be employed in chemical synthesis, chromatography techniques, ion exchange and separation techniques.

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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
    [参考文献]: A M Bersten, Et Al. Inhibition Of The Formation Of Myotubes In Vitro By Inhibitors Of Transglutaminase. Biochim Biophys Acta. 1983 Jun 2;762(3):429-36.
    [参考文献]: A Sener, Et Al. Role Of Transglutaminase In Insulin Release. Study With Glycine And Sarcosine Methylesters. Endocrinology. 1985 Jul;117(1):237-42.
    [参考文献]: C Alarcon, Et Al. Transglutaminase And Cellular Motile Events: Retardation Of Proinsulin Conversion By Glycine Methylester. Biosci Rep. 1985 Jul;5(7):581-7.
    [参考文献]: D O H Teare, Et Al. Poly(N-Acryloylsarcosine Methyl Ester) Protein-Resistant Surfaces. J Phys Chem B. 2005 Nov 10;109(44):20923-8.

    合成参考文献


    摘要:Li, Y.; Fang, X.; Wang, Y., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 70.
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