Cyclopropyldiphenylsulfonium Tetrafluoroborate置于sodium Hydride体系中,用 乙二醇二甲醚,二甲基亚砜 用作溶剂,化学反应生成环丙基苯基硫 参考文献:Preparation Of Cyclopropyldiphenylsulfonium And 2-Methylcyclopropyldiphenylsulfonium Fluoroborate And Their Ylides. Stereochemistry Of Sulfur Ylides 标题:Preparation Of Cyclopropyldiphenylsulfonium And 2-Methylcyclopropyldiphenylsulfonium Fluoroborate And Their Ylides. Stereochemistry Of Sulfur Ylides 摘要: Doi:10.1021/ja00797A034
专利号:US-6515126-B2 优先权日:2000-02-28 标 题:Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis 发明人:ASHWOOD MICHAEL STEWART; COTTRELL IAN FRANK; COWDEN CAMERON JOHN; WALLACE DEBRA JANE 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to a process for the preparation of a compound of formula (I) n wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises: n (i) cyclising a compound of formula (II) n in the presence of a suitable catalyst; and n (ii) purifying and collecting the resultant compound of formula (I).
专利号:US-2001029297-A1 优先权日:2000-02-28 标 题:Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
专利号:US-11192908-B2 优先权日:2018-08-17 标题:Octamolybdate compounds exhibiting bright emission 发明人:DANIELS STEVEN; PICKETT NIGEL; SAVJANI NICKY; GAVRILIUC VIRGIL 权利人:NANOCO 2D MAT LIMITED; UNIV MANCHESTER 摘要:Methods for the synthesis of a polyoxometalate compounds include heating a metal precursor in the presence of an organic salt. The polyoxometalate compounds produced herein display high photoluminescence quantum yields and photoluminescence maximums in the blue and/or violet regions of the electromagnetic spectrum.
专利号:WO-2023028074-A1 优先权日:2021-08-23 标 题 :Synthesis and evaluation of novel (4-hydroxyphenyl) substituted carbocycles as potent and selective estrogen receptor beta agonists
专利号:EP-1399406-B1 优先权日:2001-01-04 标题:Novel estrogen receptor ligands and methods i 发明人:KOEHLER KONRAD; HENSSEN CECILIA; NILSSON MARITA; GILLNER MIKAEL; LIU YE; SANIN ANDREI; WILKENING ROBERT R; RATCLIFFE RONALD W; WENSBO DAVID 权利人:KAROBIO AB; MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant inventive are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynecomastia, autoimmune disease, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer of the lung, colon, breast, uterus, and prrostate.
专利号:EP-4392487-A1 优先权日:2021-08-23 标题:Synthesis and evaluation of novel (4-hydroxyphenyl) substituted carbocycles as potent and selective estrogen receptor beta agonists
摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 1002. 摘要:Grogan, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 290. 参考文献:10.1007/s00894-001-0060-y 摘要:Huang W, Wilcox RE, Davis PJ. Comparative molecular field analysis (CoMFA) for sulfoxidation reactions in Mortierella isabellina ATCC 42613 and Helminthosporium sp. NRRL 4671. Journal of Molecular Modeling. 2002 Jan;8(1):8–23. doi: 10.1007/s00894-001-0060-y.