CAS: 171887-03-9; N-(2-Amino-4,6-Dichloropyrimidine-5-yl)Formamide

相似化合物

55583-59-0 89581-88-4 171887-03-9

上下游产品

CAS号64-18-6 甲酸 | CAS号55583-59-0 2,5-二氨基-4,6-二氯嘧啶 | CAS号56830-58-1 2,5-二氨基-4,6-二羟基嘧啶盐酸盐 | CAS号171887-02-8 2-amino-5-{[(di... | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号55583-59-0 2,5-二氨基-4,6-二氯嘧啶 | CAS号136470-78-5 阿巴卡韦 | CAS号171887-04-0 N-[2-氨基-4-氯-6-[...

2,5-二氨基-4,6-二氯嘧啶置于甲酸体系中,用 水,甲苯 用作溶剂,化学反应生成2-氨基-4,6-二氯-5-甲酰胺基嘧啶
参考文献:Process For The Preparation Of N-(Amino-4,6-Dihalo-Pyrimidine) Formamides
标题:Process For The Preparation Of N-(Amino-4,6-Dihalo-Pyrimidine) Formamides
摘要:一种制备n-(氨基-4,6-二卤嘧啶)甲酰胺的方法,其化学式为:其中x是卤素原子,起始物为化学式为:其中x具有上述含义的2,5-二氨基-4,6-二卤嘧啶,通过与甲酸反应.

专利信息

专利号:US-6646125-B1
优先权日:1997-10-14
标 题 :Process for the synthesis of chloropurine intermediates
发明人：JONES MARTIN FRANCIS; WALLIS CHRISTOPHER JOHN
权利人:SMITHKLINE BEECHAM CORP
摘要:The present invention relates to a process for the preparation of a carbocyclic purine nucleoside analogue of formula (I), its salts and pharmaceutically acceptable derivatives thereof which comprises hydrolysing a compound of formula (IV) wherein P is a protecting group, in the presence of an acid, condensing the product of formula (V) formed in situ in the presence of a base with a compound of formula (VI) followed by in situ ring closure of the resulting intermediate.

专利号:US-7358073-B2
优先权日:1997-11-27
标题:Process for the preparation of aminoalcohol derivatives and their further conversion to (1R, 4S)-4(2-amino-6-chloro-5-formamido-4- pyrimidinyl)-amino-2-cyclopentenyl-1-methanol
发明人：BRIEDEN WALTER; SCHROER JOSEF; BERNEGGER-EGLI CHRISTINE; URBAN EVA MARIA; PETERSEN MICHAEL; RODUIT JEAN-PAUL; BERCHTOLD KATJA; BREITBACH HOLGER
权利人:LONZA AG
摘要:The invention relates to a novel process for the preparation of an aminoalcohol of the formula n nracemically or optically active, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulaen n nIn the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl) formamide of the formulan n nto give (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulaen n nand then cyclized to give the end compounds.

专利号:WO-9919327-A1
优先权日:1997-10-14
标题 :Process for the synthesis of chloropurine intermediates

专利号:EP-1023292-B1
优先权日:1997-10-14
标 题:Process for the synthesis of chloropurine intermediates

专利号:EP-1023292-A1
优先权日:1997-10-14
标 题:Process for the synthesis of chloropurine intermediates

专利号:BG-64597-B1
优先权日:1997-10-14
标 题:METHOD FOR SYNTHESIS OF CHLOROPURINE INTERMEDIATE COMPOUNDS