CAS: 247940-06-3; 2-(Dicyclohexylphosphino)Biphenyl

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CAS号17763-65-4 (2-phenylphenyl... | CAS号829-84-5 二环己基磷 | CAS号2052-07-5 邻溴联苯 | CAS号16523-54-9 二环己氯化膦 | CAS号67-56-1 甲醇 | CAS号1186392-99-3 (2-biphenyl)dic... | CAS号583-55-1 2-溴碘苯 | CAS号98-80-6 苯硼酸 | CAS号64-17-5 乙醇 | CAS号854045-92-4 Cyclohexyl John...

1-Chloro-3-Methyl-1-Phenyl-2-Phospholenium Chloride置于六氯乙硅烷体系中,用 二氯甲烷-D2 用作溶剂,化学反应 0.08H,以333 Mg的收率获得2-(二环己基膦基)联苯
参考文献:轻度一锅还原膦(III)及其金属催化剂上的膦(v)氧化物
标题:轻度一锅还原膦(III)及其金属催化剂上的膦(v)氧化物
摘要:在温和的反应条件下,已经实现了使用草酰氯作为活化剂和六氯乙硅烷作为还原剂的一系列膦(v)氧化物的无金属还原.该方法成功地用于减少工业废物副产物三苯基膦(v)的氧化,关闭磷循环以干净地再生三苯基膦(III).机理研究和量子化学计算支持中间体phospho盐的离解氯离子对乙硅烷硅的攻击,这是脱保护的限速步骤.
Doi:10.1021/acs.Organomet.0C00788

专利信息

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-7205427-B2
优先权日:2002-06-04
标 题:Cross-coupling synthesis of alkyl (dialkylphenyl) indenes
发明人：BARNES HAMLIN H
权利人:BOULDER SCIENT CO
摘要:A cross-coupling synthesis of 2-alkyl-4-(2,6-dialkylphenyl)indenes is described. A 2-alkylidene is treated with a dialkylboronic acid in the presence of a catalyst. A feature of the invention is the use of a cross-coupling catalyst comprising palladium dichloride (1,5-cyclooctadiene) as a cross-coupling catalyst.

专利号:US-6958420-B2
优先权日:2002-07-19
标题:Synthesis of aminoarylboronic esters and substituted anilines from arenes via catalytic C-H activation/borylation/amination and uses thereof
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL
权利人:UNIV MICHIGAN STATE
摘要:A process is described for synthesizing aminoarylboronic esters of the general formula n n nwherein R, R 2 , and R 3 are each an alkyl, aryl, vinyl, alkoxy, carboxylic esters, amides, or halogen; Ar is any variety of phenyl, naphthyl, anthracyl, heteroaryl; and R 1 is alkyl, hydrogen, or aryl. The aminoarylboronic esters are produced via the metal-catalyzed coupling of arylboronic esters of the general formula n n nwherein R and R 1 are any non-interfering group and X is chloro, bromo, iodo, triflates, or nonaflates to amines (primary and secondary). In particular, a process is described for the synthesis of the aminoarylboronic esters via a step-wise or tandem process in which one catalytic event is a metal-catalyzed borylation and the other catalytic event is a metal-catalyzed amination.

专利号:US-12049470-B2
优先权日:2021-02-01
标 题 :MK2 inhibitors, the synthesis thereof, and intermediates thereto
发明人：RUCHELMAN ALEXANDER L; COOMBS JOHN R; ZHU KEMING; LIM DANIEL; JOE CANDICE LEE; GEORGE DAVID T; ZHENG BIN; LIN DONG
权利人:CELGENE CORP
摘要:The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

专利号:US-8119835-B2
优先权日:2006-12-28
标 题:Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid
发明人：KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR
权利人:KALVINSH IVARS; CHERNOBROVIJS ALEKSANDRS; TRIBULOVICH VYACHESLAV; LABEISH VLADIMIR; JSC GRINDEKS
摘要:A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one potâ€? synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suzuki-Miyaura coupling with 6-halonaphtenoates and basic hydrolysis of the reaction product in ethylene glycol or 1,2-propanediol.

专利号:US-11718584-B2
优先权日:2019-02-22
标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof
发明人：KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR
权利人:PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)