CAS: 25245-29-8; 5-Iodo-1,2,3-Trimethoxybenzene

该化合物3个有机化合物和三个与苯环相连的甲氧基化合物组的有机化合物存在,其结构表明,甲氧基苯环和甲氧基苯基化合物科学可能被用于有机合成,医药或化学反应的中间体,碘的存在可能带来有趣的生物活动,使其成为与药物发展有关的研究的一个主题.在处理和储存方面,应参考安全数据,因为卤化合物可能对健康造成危害.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号24313-88-0 3,4,5-三甲氧基苯胺 | CAS号634-36-6 1,2,3-三甲氧基苯 | CAS号6307-90-0 1,2,3-三甲氧基-5-硝基苯 | CAS号4521-61-3 3,4,5-三甲氧基苯甲酰氯 | CAS号118-41-2 3,4,5-三甲氧基苯甲酸 | CAS号106465-03-6 4-iodo-2,6-dime... | CAS号86-81-7 3,4,5-三甲氧基苯甲醛 | CAS号301823-87-0 [1,1-Biphenyl]-... | CAS号6443-69-2 3,4,5-三甲氧基甲苯 | CAS号634-36-6 1,2,3-三甲氧基苯 | CAS号56772-00-0 3,3',4,4',5,5'-... | CAS号360796-28-7 7-methoxy-4-(3,... | CAS号1504-56-9 3-(3,4,5-trimet...

合成工艺路线路线简述

    1,2,3-三甲氧基苯置于n-碘代糖精体系中,用54%的收率获得5-碘-1,2,3-三甲氧基苯
    参考文献:Aromatic Iodination Using N-Iodosaccharin In Room Temperature Ionic Liquids
    标题:Aromatic Iodination Using N-Iodosaccharin In Room Temperature Ionic Liquids
    摘要:More Reactive Iodination Conditions Have Been Developed That Combine The Use Of Room Temperature Ionic Liquids With N-Iodosaccharin. Using These Reaction Conditions,Even Very Modestly Activated Arenes Such As Toluene Can Be Iodinated In Good Yield Under Very Mild Conditions. (C) 2011 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Tetlet.2011.03.010

    海关参考信息

    专利信息


    专利号:US-2005130221-A1
    优先权日:2001-02-01
    标 题:Synthesis for the preparation of compounds for screening as potential tubulin binding agents
    发明人:FLYNN BERNARD L; HAMEL ERNEST
    权利人:US GOV HEALTH & HUMAN SERV
    摘要:The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.

    专利号:US-8674119-B2
    优先权日:2010-07-16
    标题 :Chemical processes for the manufacture of substituted benzofurans
    发明人:FLYNN BERNARD LUKE
    权利人:FLYNN BERNARD LUKE; BIONOMICS LTD
    摘要:The present invention relates to the scaled-up synthesis of biologically active compounds which display useful therapeutic activity in treating proliferative disorders. In particular the invention relates to process methods for the kilogram scale synthesis of a particular class of substituted benzofuran tubulin polymerisation inhibitors.

    专利号:CA-2435545-A1
    优先权日:2001-02-01
    标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents

    专利号:EP-1363880-A1
    优先权日:2001-02-01
    标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents

    专利号:EP-1363880-A4
    优先权日:2001-02-01
    标题:SYNTHESIS FOR THE PREPARATION OF COMPOUNDS FOR SCREENING AS POTENTIAL TUBULIN BINDING MEDIUM

    专利号:NZ-527029-A
    优先权日:2001-02-01
    标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents
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    合成参考文献


    摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 80.
    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 16.
    摘要:Waldvogel, S. R., Science of Synthesis Knowledge Updates, (2010) 1, 491.
    摘要:Xiong, Y.; Guo, R.; Zhang, G. Z., Science of Synthesis Knowledge Updates, (2021) 2, 442.
    摘要:Kalyani, D.; Desai, L. V., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 777.
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