CAS: 3934-87-0; 3,4-Dihydroxy-5-Methoxybenzaldehyde

上下游产品

5-formylvanillin 5-bromo-4-hydroxy-3-methoxybenzaldehyde 5-iodovaniline 2-bromo-3,4-dihydroxy-5-methoxy-benzaldehyde 3-methoxy-4,5-methylenedioxybenzaldehyde syringic aldehyde 3,4-diacetoxy-α-acetylamino-5-methoxy-cinnamic acid 3-(4,5-dihydroxy-3-methoxyphenyl)prop-2-enoic acid

5-溴香兰素置于铜,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应 42.0H,以70%的收率获得3,4-二羟基-5-甲氧基苯甲醛
参考文献:Tabamides A-C 及其衍生物的首次合成:体外一氧化氮抑制活性
标题:Tabamides A-C 及其衍生物的首次合成:体外一氧化氮抑制活性
摘要:天然酚醛酰胺的合成首先,Tabamides A-C(1-3),以及它们的衍生物(4-12),使用斯滔布缩合物完成和酰胺偶合反应作为关键步骤.在体外的一氧化氮(no)在lps诱导的raw-264.7巨噬细胞中这些化合物的抑制效果进行了评价抗炎活性的指标.所有测试的化合物对 Raw-264.7 巨噬细胞的 No 产生具有浓度依赖性抑制作用,而没有显着的细胞毒性.化合物6,一种 Tabamide A 衍生物 (Ic 50 = 82.6 µm),然后是 Tabamide A ( 1,Ic 50 = 100.7 µm),是该系列中最有效的.目前的研究表明,Tabamide A ( 1 ) 可以被认为是开发 No 生产靶向抗炎剂的先导结构.
Doi:10.1016/j.Tetlet.2021.153482

专利信息

专利号:US-5191077-A
优先权日:1987-05-11
标题:Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
发明人：VOLKMANN ROBERT A
权利人:PFIZER
摘要:Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(1S-oxo-3R-thiolanylthio)-2-penem-3-carboxylic acid and 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid, and pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, useful as systemic antibacterial agents; and intermediates and processes which are useful in the said synthesis of said diastereoisomers.

专利号:US-5319103-A
优先权日:1987-05-11
标 题:Intermediate diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-carboxylic acids
发明人：VOLKMANN ROBERT A
权利人:PFIZER
摘要:Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(1S-oxo-3R-thiolanylthio)-2-penem-3-carboxylic acid and 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid, and pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, useful as systemic antibacterial agents; and intermediates and processes which are useful in the said synthesis of said diastereoisomers.

专利号:CN-115403441-A
优先权日:2022-08-30
标题:A kind of synthesis method that suppresses the chlorination reaction of benzene ring in the production process of benzyl chloride

专利号:CN-1882602-A
优先权日:2003-10-10
标 题 :Modulation and degradation of hyaluronan synthesis in the treatment of disease

专利号:RU-2114852-C1
优先权日:1991-12-12
标题 :Cephem syn-isomer derivatives, method of their synthesis and pharmaceutical composition based on thereof