CAS: 4926-28-7; 2-Bromo-4-Methylpyridine

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73112-16-0 54453-91-7 1196156-17-8

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CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号108-89-4 4-甲基吡啶 | CAS号78948-09-1 acetyl hypofluorite | CAS号4411-80-7 6,6′-二甲基-2,2′-联吡啶 | CAS号1134-35-6 4,4'-二甲基-2,2'-联吡啶 | CAS号74001-75-5 4,6'-dimethyl-2... | CAS号3475-21-6 4-甲基-2-苯基吡啶 | CAS号372963-48-9 4-甲基吡啶-2-硼酸 | CAS号59576-26-0 2-乙酰基-4-甲基吡啶 | CAS号461-87-0 2-氟-4-甲基吡啶 | CAS号183483-29-6 2-(2-溴吡啶-4-基)乙酸 | CAS号18368-65-5 4-甲基吡啶-2(1H)-硫酮 | CAS号23182-19-6 2-(4-氯苯基)-4-甲基吡啶

4-甲基吡啶置于正丁基锂,N,N-二甲基乙醇胺,四溴化碳体系中,用 正己烷,四氢呋喃 作为反应溶剂,化学反应 2.0H,以70%的收率获得产物2-溴-4-甲基吡啶
参考文献:4-甲基吡啶和3,4-二甲基吡啶锂化过程中的侧链保留:轻松获得吡啶系列中的分子多样性
标题:4-甲基吡啶和3,4-二甲基吡啶锂化过程中的侧链保留:轻松获得吡啶系列中的分子多样性
摘要:4-甲基吡啶和3,4-二甲基吡啶的首次直接环选择性锂化是通过使用buli/lidmae聚集体来防止通常的侧链金属化实现的.通过环选择性顺序锂化在 C-2,C-6 和 C-5 位置引入了几种功能,为多取代吡啶构建块开辟了一条简单快速的途径.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2003)
DOI:10.1002/ejoc.200300243

专利信息

专利号:US-2008242866-A1
优先权日:2007-03-30
标 题 :Synthesis of anthranilamides
发明人：SCHMEES NORBERT; PETROV ORLIN
权利人:SCHMEES NORBERT; PETROV ORLIN
摘要:The present invention relates to a novel method of preparing anthranilamides of formula I: n n n n n n n n n n in which R 1 , R 2 , R 3 , A, E, Q, X, and W are defined in the claims, to a novel intermediate compound, and to the use of said novel intermediate compound for the preparation of said anthranilamides of formula I.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:US-9040704-B2
优先权日:2011-08-12
标题:Fluorescent dyes with large stokes shifts
发明人：PIERS WARREN EDWARD; ARANEDA JUAN FELIPE
权利人:PIERS WARREN EDWARD; ARANEDA JUAN FELIPE; UTI LIMITED PARTNERSHIP
摘要:Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed. The ligands chelate to a BF 2 center to produce the fluorescent dye. The disclosed dyes combine longer Stokes shifts (approximately 100 nm) with increased quantum yields. They are also photostable in aqueous and organic solutions for several hours. These dyes may be used in the labeling of biomolecules for bioimaging and assays. Also disclosed are methods for the synthesis of these dyes.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:CN-109232343-A
优先权日:2018-10-24
标 题 :A method for copper-catalyzed synthesis of aromatic/alkane 2,2,2-trifluoroethyl selenide and its application in pesticides