CAS: 55563-79-6; (S)-Pent-4-En-2-Ol

相似化合物

625-31-0 2883-45-6 616-25-1

上下游产品

4-戊烯-2-醇 Pent-4-En-2-Ol 625-31-0

R-10-(Trimethylsilyl)-9-Bora(och(Me)Ch2Chch2)Bicyclo[3.3.2]Decane置于(1S,2S)-2-甲氨基-1-苯基丙-1-醇体系中,用 乙腈 作为反应溶剂,化学反应 2.0H,以0.25 G的收率获得产物(S)-(+)-4-戊烯-2-醇
参考文献:使用稳健,通用且可回收的 10-Tms-9-硼双环 [3.3.2] 癸烷进行不对称烯丙基和巴豆基硼化反应
标题:使用稳健,通用且可回收的 10-Tms-9-硼双环 [3.3.2] 癸烷进行不对称烯丙基和巴豆基硼化反应
摘要:报告了 10-(三甲基甲硅烷基)-9-硼双环 [3.3.2] 癸烷 (10-Tms-9-Bbd) 在代表性醛的烯丙基和巴豆基硼化反应中的显着多功能性和选择性.新试剂是通过 10-Tms-9-Bbd (4) 的空气稳定结晶伪麻黄碱硼酸酯复合物制备的,通过简单的两步程序可以从 B-Meo-9-Bbn 中获得 63% 的总产率. 这些配合物 4 与烯丙基溴化镁直接转化为相应的 B-烯丙基-10-Tms-9-Bbds (1),可以分离 (98%) 或原位用于烯丙基化.这些试剂在-78 摄氏度的快速(<3 小时),不对称烯丙基硼化过程中显着的对映选择性(96 至 > 或 = 99% Ee)在 25 摄氏度下进行时仅略微减弱,一种归因于其刚性双环结构的现象.除了有效地提供高烯丙醇 6 (68-80%),该程序还允许有效回收 4 (68-84%) 以直接再生 1.或者,氧化后处理程序可用于制备6. 该试剂提供可预测的立体化学,并在
DOI:10.1021/ja043612I

专利信息

专利号:US-9771379-B2
优先权日:2015-09-24
标题:N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 , R 2 , R 3 , R 4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9744173-B2
优先权日:2014-04-10
标题 :2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; BARREIRO GABRIELA; LACHAPELLE ERIK ALPHIE; ROGERS BRUCE NELSEN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variable R 1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9198917-B2
优先权日:2012-12-11
标题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; DAVOREN JENNIFER ELIZABETH; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure n nwherein the variables R 1 , R 2 , R 3 , R 4 and x are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-112979605-A
优先权日:2021-03-03
标题:A kind of stable isotope labeled zearalenone and its synthesis method