CAS: 640-87-9; 2-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-10,13-Dimethyl-3-Oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)-2-Oxoethyl Acetate

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CAS号108-22-5 醋酸异丙烯酯 | CAS号152-58-9 可托多松 | CAS号19357-45-0 17,21-dihydroxy... | CAS号63973-94-4 17α-hydroxy-20-... | CAS号20380-17-0 21-bromo-17α-hy... | CAS号108-24-7 乙酸酐 | CAS号127-08-2 醋酸钾 | CAS号57273-80-0 17α-Acetoxy-21-... | CAS号481-29-8 表雄酮 | CAS号1807-15-4 Pregn-4-ene-3,2... | CAS号54201-62-6 3,17α,21-triace... | CAS号63-05-8 雄烯二酮 | CAS号312-99-2 5-ALPHA-DIHYDRO... | CAS号152-58-9 可托多松 | CAS号566-12-1 9α-hydroxycorte...

17Alpha-羟基黄体酮置于盐酸,溴体系中,用 甲醇,乙醇 作为反应溶剂,化学反应 15.5H,反应生成 孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯
参考文献: Process For The Production Of 21-(Acetyloxy)-17-(Propionyloxy)-Pregn-4-Ene-3,20-Dione[fr] Procédé De Production De 21-(Acétyloxy)-17-(Propionyloxy)-Prégn-4-ène-3,20-Dione
标题: Process For The Production Of 21-(Acetyloxy)-17-(Propionyloxy)-Pregn-4-Ene-3,20-Dione[fr] Procédé De Production De 21-(Acétyloxy)-17-(Propionyloxy)-Prégn-4-ène-3,20-Dione
摘要:The Present Invention Relates To A Process For The Preparation Of 21-(Acetyloxy)-17-(1-Oxopropoxy)-Pregn-4-Ene-3,20-Dione (Vi) Having The Formula Below: Compound (Vi) Can Be Used As A Precursor For The Synthesis Of Clascoterone,A Steroid Used For The Treatment Of Acne.

专利信息

专利号:US-4041055-A
优先权日:1975-11-17
标题:Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes
发明人：SHEPHARD KENNETH PAUL; VAN RHEENEN VERLAN H
权利人:UPJOHN CO
摘要:This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17α-hydroxyprogesterones and the corticoids.

专利号:US-5502183-A
优先权日:1992-01-28
标 题 :Steroid intermediates and processes for their preparation
发明人：ANDREWS DAVID R; SUDHAKAR ANANTHA R
权利人:SCHERING CORP
摘要:PCT No. PCT/US93/00211 Sec. 371 Date Jul. 25, 1994 Sec. 102(e) Date Jul. 25, 1994 PCT Filed Jan. 26, 1993 PCT Pub. No. WO93/15103 PCT Pub. Date Aug. 5, 1993.Novel steroids having a 9 alpha -hydroxy or a 9 alpha -carbonate substituent can be prepared from 9 alpha -hydroxyandrostenedione and can be utilized in the synthesis of commercially valuable corticosteroids such as betamethasone. The 9 alpha -carbonates are prepared by reaction of the corresponding 9 alpha -hydroxy steroid with a sequence of excess base, trialkylsilyl chloride, alkyl haloformate and alkanol or by using excess base, alkyl haloformate and alkoxide. 9 alpha -Carbonate-17-keto compounds can be treated with lithium acetylide and a lithium salt to afford the corresponding 17 alpha -ethynyl-17 beta -hydroxy-9 alpha -carbonate. This compound is then esterified with a novel series of reagents to give the 17-ester which can be reduced the corresponding 17-allene. Oxidation of this allene to the bis-epoxide compound, followed by treatment with an alkali metal salt of a carboxylic acid under phase transfer conditions gives the 17 alpha -hydroxy 21-ester 9 alpha -carbonate. Elimination of the 9 alpha -carbonate group affords the a 17 alpha -hydroxy, 9(11)ene, which in a few subsequent steps can be converted to a variety of commercially important corticosteroids. Novel 9 alpha -carbonate compounds are prepared in the various reaction steps.