专利号:WO-2025132776-A1 优先权日:2023-12-20 标题 :Use of iron-based compounds for the synthesis of borated compounds, and corresponding methods 发明人:HANNEDOUCHE JÉRÔME; BEZZENINE SOPHIE; GIL RICHARD; CHEN DONGHUANG; WOWK VINCENT 权利人:UNIV PARIS SACLAY; CENTRE NAT RECH SCIENT 摘要:The present invention relates to the use of iron-based compounds for the synthesis of borated compounds, and the corresponding methods.
专利号:US-3821231-A 优先权日:1971-10-15 标 题 :Method for preparation of n-substituted 4-aniline piperidines 发明人:LAVRINOVICH E; GERMANE S; TREIGUTE I; EDZHIN M 权利人:LAVRINOVICH E; GERMANE S; TREIGUTE I; EDZHIN M 摘要:A method for the preparation of N-substituted 4-anilino piperidines having the general formula WHERE R is an alkyl group having from 1 to 16 carbon atoms, C6H5CH2-, or C6H5(CH2)2-, comprising reacting 4-anilinopyridine with an alkyl or aralkyl halide having the general formula R-X, where R is an alkyl group having from 1 to 16 carbon atoms, C6H5CH2-, or C6H5(CH2)2- and X is Cl, Br or I, with subsequent reduction of the formed N-substituted 4-anilinopyridinium quarternary salt with sodium borohydride in an aqueous-organic solvent and isolation of the main product. The proposed invention can be used in the synthesis of certain medical preparations, for example analgesic phentanyl and some other physiologically active compounds.
专利号:US-5922889-A 优先权日:1996-06-21 标题 :Synthesis of isochromans and their derivatives 发明人:CUTLER HORACE G; MAJETICH GEORGE; TIAN XINRONG; SPEARING PAUL 权利人:US AGRICULTURE; UNIV GEORGIA 摘要:Isochromans and their derivatives have been chemically synthesized. These compounds possess significant phytotoxic activity which may be used as a biodegradable contact herbicide. The synthetic method allows for economic production of these herbicides.
专利号:WO-2021133280-A1 优先权日:2019-12-27 标 题 :An improved process for preparation of scopine hydrobromide 发明人:HAAS PHILIPP DANIEL; STECKEL HARTWIG ANDREAS; BELLUR ATICI ESEN; AYDIN FATMA GÖZDE 权利人:DEVA HOLDING 摘要:The present invention relates to an efficient and industrially advantageous process for the preparation of scopine free base or salts. Said compounds are important intermediates in the synthesis of tiotropium and pharmaceutically acceptable salts thereof. The method provided for preparing scopine free base or its salts has the advantages of a simple operation, high yield and low costs.
专利号:US-4432906-A 优先权日:1981-09-14 标 题 :Inhibitors of SRS-synthesis 发明人:COHEN NOAL; WEBER GIUSEPPE 权利人:HOFFMANN LA ROCHE 摘要:Methyl derivatives of arachidonic acid and intermediates thereto have been synthesized. These derivatives are inhibitors of SRS-A synthesis and are useful for treating and preventing allergic reactions.
专利号:WO-2018055642-A1 优先权日:2016-09-23 标 题:A process for preparing tiotropium bromide and intermediates thereof 发明人:REDDY G NITHUN; REDDY G SAMHITHA; REDDY G MADAALASA; RAMANI M; REDDY G PRATAP 权利人:GBR LABORATORIES PVT LTD; RACHANA PHARMA TECH 摘要:Provided herein is a process for synthesis of tiotropium bromide and a process for synthesis of scopine starting from a dimethyl tartarate compound. The synthetic sequence comprises a double Mannich reaction (Robinson-Schopf reaction).
摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 76. 摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 38. 摘要:Yamazaki, T., Science of Synthesis Knowledge Updates, (2017) 2, 293. 摘要:Margaretha, P., Science of Synthesis Knowledge Updates, (2014) 2, 459. 摘要:Braun, M., Science of Synthesis Knowledge Updates, (2017) 1, 444.