专利号:WO-2025035571-A1 优先权日:2023-08-15 标 题 :Process for recycling waste residue from synthesis of hexachlorocyclotriphosphazene 发明人:LONG ZHI; WANG QIUWEI; LIN PING; YAN ZHIWEI; YE JUN 权利人:ZHEJIANG WANSHENG CO LTD 摘要:Provided is a process for recycling waste residue from the synthesis of hexachlorocyclotriphosphazene. The process comprises: reacting waste residue separated out after a synthesis reaction of hexachlorocyclotriphosphazene is finished with an ammonia source, the ammonia source being liquid ammonia, ammonia gas, ammonia water, ammonium bicarbonate, ammonium carbonate or a combination thereof; adjusting the pH value at an end point to 6-10; subjecting the obtained reaction product to solid-liquid separation so as to obtain a filtrate and a filter cake; subjecting the filter cake to post-treatment so as to obtain a recovered metal chloride catalyst; extracting the filtrate by using chlorobenzene, i.e. an extracting agent, so as to obtain an extract phase and a raffinate phase; rectifying the extract phase to obtain chlorobenzene and recovered pyridine or pyridine derivatives; and dehydrating the raffinate phase to obtain recovered ammonium chloride. By means of the process, high-degree recycling and regeneration of waste residue from the synthesis of hexachlorocyclotriphosphazene are achieved, the recovery rate of pyridine or pyridine derivatives from the waste residue can reach 95-99% or higher, the recovery rate of ammonium chloride and the metal chloride catalyst can reach 98% or higher, and no new waste residue is generated throughout the whole process.
专利号:US-2023313255-A1 优先权日:2020-07-15 标题:Massively Parallel Enzymatic Synthesis of Polynucleotides 发明人:HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER 权利人:DNA SCRIPT 摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.
专利号:US-2025257380-A1 优先权日:2023-01-31 标 题:Method for template-free de novo synthesis of long-chain nucleic acid, and use thereof 发明人:XU CHENG; LIU YUANXIAO 权利人:SHANGHAI TYPING BIOSCIENCE CO LTD 摘要:The present application relates to the fields of molecular biology and biotechnology, and in particular to a method for template-free de novo synthesis of a long-chain nucleic acid, including the following steps: S1, synthesis of double-stranded oligonucleotides; and S2, combination and ligation of the double-stranded oligonucleotides to obtain a target long-chain nucleic acid. The present application achieves continuous synthesis from single nucleotides to long-chain nucleic acids by means of the combination of S1 and S2, and has the advantages of no need for templates, high accuracy, low complexity and low cost.
专利号:US-7615169-B2 优先权日:2004-09-20 标题 :Method for synthesis of colloidal nanoparticles 发明人:STROUSE GEOFFREY FIELDING; GERBEC JEFFREY A; MAGANA DONNY 权利人:UNIV CALIFORNIA 摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.
专利号:US-12421628-B2 优先权日:2018-07-23 标题:Massively parallel enzymatic synthesis of nucleic acid strands 发明人:HORGAN ADRIAN; GODRON XAVIER; YBERT THOMAS; NICOL ROBERT 权利人:DNA SCRIPT 摘要:The invention is directed to methods for massively parallel template-free enzymatic synthesis of a plurality of different polynucleotides of predetermined sequences. In one aspect, methods of the invention employ large scale arrays of reaction sites each associated with at least one working electrode for controlling deprotection and deblocking steps at predetermined user selected sites. In another aspect, the invention provides template-free enzymatic synthesis with proofreading, wherein completed polynucleotides at predetermined reaction sites are sequenced using a sequencing by synthesis technique, particularly employing electrochemically labile blocking groups.
专利号:US-8975340-B2 优先权日:2010-12-15 标题 :Synthesis of sequestration resins for water treatment in light water reactors 发明人:YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN 权利人:YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN; ELECTRIC POWER RES INST 摘要:An organic synthesis of materials to achieve removal of low molecular weight ionic species, such as transition metal ions including cobalt, iron, nickel, and zinc, from aqueous solutions. The synthesis includes the steps of providing a cation exchange resin, functionalizing the cation exchange resin using a chloride intermediate to form a sulfonyl chloride resin, and reacting a multi-amine based ligand with the sulfonyl chloride resin to form a sequestration resin. The synthesis further includes the steps of cooling the sequestration resin, and washing and drying the sequestration resin.
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