CAS: 78137-76-5; 4-Bromo-3-Nitrophenol

上下游产品

CAS号5344-78-5 4-溴-3-硝基苯甲醚 | CAS号554-84-7 3-硝基苯酚 | CAS号610-81-1 3-硝基-4-氨基苯酚 | CAS号2243-69-8 Acetamide,N-[4-... | CAS号99-09-2 间硝基苯胺 | CAS号7726-95-6 溴素 | CAS号4514-28-7 4-(苄氧基)-1-溴-2-硝基苯

间硝基苯酚置于1,2-Ethanediylbis(Triphenylphosphonium) Ditribromide体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 0.08H,以85%的收率获得产物4-溴-3-硝基苯酚
参考文献:在溶剂存在下和无溶剂条件下合成1,2-乙二基双(三苯基phosph)二溴化新溴化剂
标题:在溶剂存在下和无溶剂条件下合成1,2-乙二基双(三苯基phosph)二溴化新溴化剂
摘要:摘要定量制备了1,2-乙二烷基双(三苯基))二三溴化物,并在混合溶剂系统(dcm / Meoh 2:1)的存在下以及在无溶剂条件下用于苯胺和苯酚的溴化.这种新型离子液体在反应时间短,后处理简单,区域选择性高和产率方面均优于同类溴化剂.标题盐的单晶x射线分析表明,双三苯基phosph阳离子围绕位于-ch 2-ch 2-桥中心的反型中心周围组织,并且两个三苯基膦链段彼此相对.所有三溴化物阴离子均采用线性几何结构,每个阴离子具有不同的br-br-br键角. 图形概要
DOI:10.1007/s13738-016-0919-6

专利信息

专利号:US-5545568-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of compounds on a solid support
发明人：ELLMAN JONATHAN A
权利人:UNIV CALIFORNIA
摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

专利号:US-12384788-B2
优先权日:2019-09-13
标 题 :1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
发明人：KOESTLER ROLAND; TASSEL JEAN; THORMANN MICHAEL; YEHIA NASSER; TREML ANDREAS; ALMSTETTER MICHAEL
权利人:ORIGENIS GMBH
摘要:The present invention relates to compounds of formula (I) that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 40 to 146; examples 1 to 63; compounds 1 to 248; tables 1 to 3). Preferred compounds are e.g. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds. An exemplary compound is e.g. 5-(2,6-difluorophenyl)-8-methoxy-1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine (example 49). (Formula (II):

专利号:WO-9406291-A1
优先权日:1992-09-14
标 题:Solid phase and combinatorial synthesis of compounds on a solid support

专利号:CN-115960074-A
优先权日:2022-05-27
标题 :A class of fluorine-containing ferroelectric liquid crystal molecules containing a heteroatom six-membered alicyclic ring and its synthesis method

专利号:CN-109096249-B
优先权日:2018-08-13
标 题 :Synthesis method of aripiprazole

专利号:CN-110143852-A
优先权日:2019-06-28
标 题:A method of photocatalytic synthesis is at more bromophenol compounds in water phase