CAS: 934987-26-5; 2-Bromo-3,6-Difluorobenzaldehyde

该化合物是一种芳香化合物,其特点是存在一种苯并二丁二烯功能组,其特点是直接附于苯环的碳基(C=O),该化合物含有两个氟原子和一个溴原子替代物,在苯环上,具体地说,该化合物的3和6个位置与正丁组有关,以及位于2个位置的溴原子有关.这些卤素替代物的存在对化合物的再活动性和物理特性,例如其沸点和熔点,溶解度和极度等产生重大影响.一般而言,卤化芳烃化合物具有独特的电子特性,因为卤素的电阴性性质会影响其在化学反应中的行为,包括电药性芳香替代物.2-Bromo-3-6-二氟苯并二苯乙酰胺可被用于各种用途,包括有机合成,以及作为生产制药或农化化学品过程中的中间体.在处理该化合物时,应观测与该化合物潜在危害有关的有机剂时,应观测安全防范.

英文名称2-Bromo-3,6-Difluorobenzaldehyde
中文名称2-溴-3,6-二氟苯甲醛
IUPAC名称2-bromo-3,6-difluorobenzaldehyde
其它别名Pqxmbfzkkqnhba-Uhfffaoysa-N; 2-Bromo-3,6-Difluorobenzaldehyde,96%; 2-Bromo-3,6-Difluorobenzaldehyde; 2-Bromo-3,6-Difluoro-Benzaldehyde; Cs-W
CAS编号934987-26-5
MFCD编号:MFCD12922618
EINECS号:688-047-9
分子式:C7H3BrF2O
分子量:221.0
产品CID: 1974596
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: PQXMBFZKKQNHBA-UHFFFAOYSA-N
InChI=1S/C7H3BrF2O/c8-7-4(3-11)5(9)1-2-6(7)10/h1-3H…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P302+P352-P304+P340
危险品标志Xi

欧盟法规

ECHA物质C&L通报

上下游产品

N,N-dimethyl-formamide 2-bromo-1,4-difluorobenzene 2-bromo-3-fluorobenzaldehyde 4-bromo-5-fluoro-1-(4-fluorophenyl)-1H-indazole 4-bromo-5-fluoro-1H-indazole (2-bromo-3,6-difluorophenyl)methanol 8H4BrF2NC8H4BrF2N

合成工艺路线路线简述

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -70 °C; 45 Min,-70 °C1.2 2 H,-70 °C; -70 °C -> 0 °C
标题:Azaaryl Compound,And Preparation Method Therefor And Use Thereof
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran,Water; -70 °C; 45 Min,-70 °C1.2 2 H,-70 °C; -70 °C -> 0 °C
标题:Preparation Of Aza-Heteroaryl Compound And Application Thereof
参考文献:China]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran,Water; -70 °C; 45 Min,-70 °C1.2 2 H,0 °C
标题:Preparation Of The Pyrimidone Compound And Their Application As The Anticancer Agents
参考文献:China]

891180-59-9 = 934987-26-5
反应条件:1.1 Reagents: Pyridinium,1-Fluoro-2,4,6-Trimethyl-,1,1,1-Trifluoromethanesulfonate (1:1) Catalysts: Aniline-2,4-Disulfonic Acid,Palladium Diacetate Solvents: 1,2-Dichloroethane; 10 H,Rt; 24 H,110 °C
标题:Pd-Catalyzed,Ortho C-H Methylation And Fluorination Of Benzaldehydes Using Orthanilic Acids As Transient Directing Groups
作者:Chen,Xiao-Yang; Sorensen,Erik J.
参考文献:Journal Of The American Chemical Society 日期:2018 卷标:140(8) 页码:2789-2792]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -78 °C; 45 Min,-78 °C1.2 2 H,-78 °C
标题:Preparation Of Triazolopyrimidine Compounds Useful In The Treatment Of Diseases Or Disorders Mediated By Eed And/or Prc2
参考文献:United States]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; 1 H,-78 °C1.2 2 H,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water; 0 °C
标题:Preparation Of Macrocyclic Compounds As Src And Met,And/or Csf1R Inhibitors
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C1.2 Solvents: Dimethylformamide; -78 °C; 2 H,-78 °C; -78 °C -> Rt1.3 Reagents: Ammonium Chloride Solvents: Water; Rt
标题:Fused Bicyclic Compounds As Ask1 Activity Regulators And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Diseases
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C1.2 -78 °C; 30 Min,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water
标题:Preparation Of Cyclohexyl-Ethyl Substituted Diaza- And Triaza-Tricyclic Compounds As Indole-Amine-2,3-Dioxygenase (Ido) Antagonists For The Treatment Of Cancer
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C1.2 -78 °C; 1 H,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water
标题:Preparation Of (5-Fluoro-2,3-Dihydrobenzofuran-4-Yl)Methanamine Hydrochloride
参考文献:China]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -70 °C; 45 Min,-70 °C1.2 2 H,-70 °C; -70 °C -> 0 °C
标题:Process For Preparation Of Azaheteroaryl Compound And Application Thereof
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -70 °C; 45 Min,-70 °C1.2 2 H,-70 °C
标题:Pyridine Or Pyridazine Cyclic Compound And Application Thereof In Preparing Drugs For Treating Cancer Diseases Or Disorders
参考文献:China]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -65 °C; 30 Min,-65 °C1.2 2 H,-65 °C1.3 Reagents: Ammonium Chloride Solvents: Water
标题:Nitrogen Oxide Compound Or Pharmacologically Acceptable Salt Thereof And Preparation Method And Application Thereof
参考文献:China]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; 30 Min,-78 °C; 1 H,-78 °C1.2 30 Min,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water; Rt
标题:Preparation Of Benzenesulfonamide Compounds And Their Use As Therapeutic Agents
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; 1 H,-78 °C1.2 2 H,-78 °C; -78 °C -> 0 °C1.3 Reagents: Ammonium Chloride Solvents: Water; 0 °C
标题:Macrocyclic Compound,Pharmaceutical Composition,And Use Thereof
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; 30 Min,-78 °C1.2 15 Min,-78 °C1.3 Reagents: Acetic Acid Solvents: Water; -78 °C
标题:Preparation Of (Aza)Pyridopyrazolopyrimidinones And Indazolopyrimidinones And Their Use For Treating Or Preventing Diseases
参考文献:United States]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran,Hexane; 15 Min,< -65 °C; 1 H,-78 °C1.2 30 Min,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water; -78 °C; -78 °C -> Rt
标题:Indazole Derivatives As Estrogen Receptor Beta Mediators And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Diseases
参考文献:World Intellectual Property Organization]

399-94-0 = 934987-26-5
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; -70 °C; 30 Min,-75 °C1.2 Reagents: Dimethylformamide; -70 °C; 30 Min,-70 °C1.3 Reagents: Sulfuric Acid Solvents: Water
标题:Preparation Of Indazolyl-Substituted Sulfonamides And Analogs As Glucocorticoid Receptor Modulators In The Treatment Of Inflammatory Diseases
参考文献:World Intellectual Property Organization

2-溴-3-氟苯甲醛置于苯胺-2,4-二磺酸,Palladium Diacetate,1-氟-2,4,6-三甲基吡啶三氟甲烷磺酸盐体系中,化学反应 24.0H,以69%的收率获得产物2-溴-3,6-二氟苯甲醛
参考文献:使用邻苯甲酸作为瞬态导向基团的 Pd 催化,邻位 Ch 甲基化和苯甲醛氟化
标题:使用邻苯甲酸作为瞬态导向基团的 Pd 催化,邻位 Ch 甲基化和苯甲醛氟化
摘要:直接的,Pd 催化的邻位 Ch 甲基化和苯甲醛氟化已经使用市售的邻苯甲酸作为瞬时导向基团完成.在这些反应中,1-氟-2,4,6-三甲基吡啶鎓盐可以是旁通的 F+ 氧化剂或亲电子氟化试剂.使用三苯基膦作为稳定配体获得苯甲醛邻位 Ch 钯化中间体的 X 射线晶体结构.
DOI:10.1021/jacs.8B00048

海关参考信息

2912110000-甲醛
2912210000-苯甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-12428380-B2
优先权日:2023-06-28
标题 :Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.

其他信息查阅

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合成参考文献

参考文献:10.1055/s-0036-1591937
摘要:Beverina L, Vaghi L, Sanzone A, Sassi M, Pagani S, Papagni A. Synthesis of Fluorinated Acridines via Sequential Micellar Buchwald–Hartwig Amination/Cyclization of Aryl Bromides. Synthesis. 2018 Feb 26;50(08):1621–8. doi: 10.1055/s-0036-1591937.