CAS: 10068-67-4; Z-Tyr(Tbu)-Osu

化学文摘社编号10068-67-4,该物质具有氨基化合物功能组的特点.该物质具有苯甲基乙基酯的特性,有助于其再活性和溶性.存在一种苯丙基苯基化合物组表明潜在的生物活动,因为许多含有此类结构的化合物因其药理效应而已知.该化合物的结构表明,由于大宗二甲基苯氧基和苯基化合物组群可能表现出中度的脂性较高,这可能会影响其与生物膜的相互作用.此外,多种功能组的存在,包括碳基和醚,可能会为进一步的化学再活性或变异性提供场所.

英文名称Z-Tyr(Tbu)-Osu
中文名称Z-酪氨酸-(TBU)-OSU
IUPAC名称2,5-dioxopyrrolidin-1-yl (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoate
其它别名N-Alpha-Benzyloxycarbonyl-O-T-Butyl-L-Tyrosine Succinimidyl Ester; Z-L-Tyr(Tbu)-Osu; Z-O-Benzyl-L-Tyrosine Hydroxysuccinimidester; 1-[(S)-3-[4-(1,1-Dimethylethoxy)Phenyl]-1-Oxo-2-[[(Benzyloxy)Carbonyl]Amino]Propoxy]-2,5-Pyrrolidinedione; Z-O-Tert-Butyl-L-Tyrosinen-Hydroxysuccinimide Ester≥ (Hplc); Carbamic Acid, [(1S)-1-[[4-(1,1-Dimethylethoxy)Phenyl]Methyl]-2-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-2-Oxoethyl]-, Phenylmethyl Ester (9Ci); N-Alpha-Cbz-O-T-Butyl-L-Tyrosine N-Hydroxysuccinimide Ester; Z-O-T-Butyl-L-Tyrosine N-Hydroxysuccinimide Ester
CAS编号10068-67-4
MFCD编号:MFCD00153350
分子式:C25H28N2O7
分子量:468.51
产品CID: 16172
产品分类生物化工 → 氨基酸及其衍生物 → 酪氨酸类衍生物

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InChIKey: UQLJTOVTUWDKCW-FQEVSTJZSA-N
InChI=1S/C25H28N2O7/c1-25(2,3)33-19-11-9-17(10-12-19)15-20(23(30)34-27-21(28)13-14-22(27)29)26-24(31)32-16-18-7-5-4-6-8-18/h4-12,20H,13-16H2…
计算化学: 氢键受体数7.0氢键供体数1.0可旋转键数11.0

MSDS等安全信息

合成工艺路线路线简述

专利信息

专利号:US-3862113-A
优先权日:1972-09-22
标题 :Process for the selective elimination of aralkyloxycarbonyl and trityl n-protecting groups with 2,2,2-trifluoroethanol
发明人：RINIKER BERNHARD; KAMBER BRUNO; SIEBER PETER
权利人:CIBA GEIGY CORP
摘要:A process for the selective elimination of amino protective groups in peptide synthesis, wherein the trityl group and/or an aralkyloxycarbonyl group such as the 2-(p-bi-phenylyl)-2propyloxycarbonyl group is (are) split off in trifluorethanol at a pH of about 4 or 1, respectively.