CAS: 107496-54-8; 3,3-Difluorocyclobutanecarboxylic Acid

相似化合物

86770-80-1 681128-39-2 1234616-13-7

上下游产品

3,3-二氟-环丁烷羧酸甲酯 Methyl 3,3-Difluorocyclobutane-1-Carboxylate 1234616-13-7
3,3-二氟环丁烷羧酸乙酯 Ethyl 3,3-Difluorocyclobutane-1-Carboxylate 681128-38-1

2-Chloro-3,3-Difluorocyclobut-1-Ene Carboxylic Acid置于palladium 10% On Activated Carbon,氢气,三乙胺体系中,用 甲醇 用作溶剂,45.0~50.0 °C,344.75 Kpa 条件下,以95%的收率获得3,3-二氟环丁烷羧酸
参考文献:3,3-偕二氟环丁基甲酸工业化制备方法
标题:3,3-偕二氟环丁基甲酸工业化制备方法
摘要:本发明涉及一种3,3-偕二氟环丁基甲酸的工业化制备方法.主要解决现有制备方法存在的原料3-氧代环丁羧酸或3-亚甲基环丁基甲腈,和氟代试剂dast价格昂贵,不能规模化生产的技术问题.本发明以常规,易得的丙烯酸甲酯和1,1-二氯-2,2-二氟乙烯为原料,通过加成,水解,氢化得到3,3-偕二氟环丁基甲酸.其化学反应式如下:,本发明提供了一种简易实用,制备成本较低的3,3-偕二氟环丁基甲酸的工业化制备方法.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-9745253-B2
优先权日:2015-03-13
标 题 :Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
发明人：BAIR KENNETH W; Barczak Nicholas; HAN BINGSONG; LANCIA JR DAVID R; LIU CUIXIAN; MARTIN MATTHEW W; NG PUI YEE; Rudnitskaya Aleksandra; THOMASON JENNIFER R; ZABLOCKI MARY MARGARET; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.