专利号:US-8962851-B2 优先权日:2011-12-27 标题:One-pot process for the preparation of benzimidazole derivatives 发明人:DWIVEDI SHRIPRAKASH DHAR; PRASAD ASHOK; PAL DAYA RAM 权利人:CADILA HEALTHCARE LTD 摘要:The present invention discloses one pot process for enantioselective synthesis of single enantiomers of substituted sulphoxides 2-(2-pyridinylmethylsulphinyl)-1H-benzimidazoles or said compounds in an enantiomerically enriched form.
专利号:US-9428486-B1 优先权日:2014-07-29 标 题 :Efficient process for the preparation of Esomeprazole (S)-Binol complex 发明人:STABILE PAOLO; BERTOLAZZI MORENO; FACCIN NICOLA; RASIA DIEGO 权利人:F I S - FABBRICA ITALIANA SINTETICI S P A; F I S —FABBRICA ITALIANA SINTETICI S P A 摘要:Object of the present invention is an improved process for the preparation of Esomeprazole (S)-BINOL complex which is a key intermediate for the synthesis of Esomeprazole and salts thereof.
专利号:US-2006166986-A1 优先权日:2004-05-28 标题 :Novel stereoselective synthesis of benzimidazole sulfoxides
专利号:ES-2338556-T3 优先权日:2004-05-28 标 题:NOVEDOUS STEREOSELECTIVE SYNTHESIS OF SULFOXIDES OF BENZIMIDAZOL.
专利号:US-2008076929-A1 优先权日:2004-05-28 标 题:Novel stereoselective synthesis of benzimidazole sulfoxides
专利号:US-7365206-B2 优先权日:2004-05-28 标题:Stereoselective synthesis of benzimidazole sulfoxides
参考文献:10.1080/14756366.2022.2070909 摘要:Kaur S, Nieto NS, McDonald P, Beck JR, Honzatko RB, Roy A, Nelson SW. Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022 May 05;37(1):1320–6. doi: 10.1080/14756366.2022.2070909.