CAS: 223463-13-6; 5-Bromo-2-Iodopyridine

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CAS号624-28-2 2,5-二溴吡啶 | CAS号1072-97-5 2-氨基-5-溴吡啶 | CAS号111770-81-1 5-bromo-2-(hex-... | CAS号38749-90-5 2-乙基-5-溴吡啶 | CAS号436799-32-5 5-溴-2-(三氟甲基)吡啶 | CAS号39919-58-9 5-溴-2-叔丁基吡啶 | CAS号463336-07-4 5-溴-2-(4-氟苯基)吡啶 | CAS号223556-42-1 4-(5-溴-2-吡啶基)硫代吗啉 | CAS号183619-13-8 5-溴-2-(4-溴苯基)吡啶 | CAS号294851-95-9 4-[(5-溴-2-吡啶)甲基]-吗啉 | CAS号27012-25-5 5-溴-2-苯基吡啶 | CAS号874959-68-9 5-溴吡啶-2-磺酰氯

2,5-二溴吡啶置于三甲基氯硅烷,Sodium Iodide体系中,用 Various Solvent(S) 用作溶剂,化学反应 125.0H,以87%的收率获得5-溴-2-碘吡啶
参考文献:三氟甲基取代的吡啶羧酸和喹啉羧酸的推荐路线
标题:三氟甲基取代的吡啶羧酸和喹啉羧酸的推荐路线
摘要:作为案例研究的一部分,准备的合理策略.所有 10 种 2-,3-或 4-吡啶羧酸和所有 9 种在 2-,3-或 4-位带有三氟甲基取代基的 2-,3-,4-或 8-喹啉羧酸中的 如果前体中尚未存在三氟甲基,则通过用四氟化硫对合适的羧酸进行脱氧氟化或通过原位生成的三氟甲基铜置换环结合的溴或碘来引入三氟甲基.羧基功能是通过用二氧化碳处理有机锂或有机镁中间体,卤素/金属或氢/金属置换的产物而产生的.[在 Scifinder (R) 上]
Doi:10.1002/ejoc.200390215

专利信息

专利号:EP-4186890-A1
优先权日:2021-11-29
标题 :Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin
发明人：ARE CELESTE; BALLETTE ROBERTO; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:The present invention relates to a process for the preparation of N-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide, which is a suitable intermediate for the synthesis of tirbanibulin or a pharmaceutically acceptable salt thereof, as well as to a process for the preparation of tirbanibulin or a pharmaceutically acceptable salt thereof using said N-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide intermediate.

专利号:US-6635767-B2
优先权日:2000-05-23
标 题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K; KAPADIA SURESH R
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-6822093-B2
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-2003135046-A1
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds

专利号:US-10125101-B2
优先权日:2016-11-28
标题:Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
发明人：ECKHARDT MATTHIAS; WAGNER HOLGER; PETERS STEFAN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R, R 1 , R 2 , R 3 , m and n are as defined herein, which compounds have valuable pharmacological properties, in particular their ability to bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular type 2 diabetes. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:CA-2424916-C
优先权日:2000-05-23
标 题:Novel synthesis of heteroarylamine intermediate compounds