CAS: 2899-36-7; Ethyl L-Methionate Hydrochloride

相似化合物

6297-53-6 2899-37-8 348-67-4

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CAS号64-17-5 乙醇 | CAS号63-68-3 L-蛋氨酸 | CAS号2899-37-8 L-(-)-蛋氨醇 | CAS号117196-96-0 ethyl (2S)-2-[[...

乙醇,L-蛋氨酸置于氯化亚砜体系中,化学反应 25.0H,反应生成L-蛋氨酸乙酯盐酸盐
参考文献:用于水杨酸转化为离子液体的生物相容性氨基酸酯的表征和细胞毒性评估
标题:用于水杨酸转化为离子液体的生物相容性氨基酸酯的表征和细胞毒性评估
摘要:图形化的抽象图.没有可用的字幕.&na; 活性药物成分(api)转化为离子液体(ils)后,其技术实用性将大大提高.与固体或结晶药物相比,Api‐il具有更好的溶解性,热稳定性和局部给药功效.但是,Api-Ils的毒理学问题是其在药物输送中的主要挑战.为了解决这个问题,合成了11种氨基酸酯(aae)并作为水溶性低的药物水杨酸(sal)形成sal-Il的生物相容性抗衡阳离子进行了研究.使用1 H和13 C NMR,Ftir,元素分析和热重分析对aae进行表征.使用哺乳动物细胞系(l929和hela)研究了aae阳离子,Sal-Ils和游离sal的细胞毒性.随着阳离子侧基中包含长烷基链,硫和芳香环,Aae阳离子的毒性大大提高.选择丙氨酸,天冬氨酸和脯氨酸乙酯作为低细胞毒性aae.与sal结合到阳离子中的aae相比,Sal‐ils的细胞毒性急剧增加,与游离sal相当.有趣的是,Sal-Il的水混
Doi:10.1016/j.Ijpharm.2018.05.021

专利信息

专利号:US-9556301-B1
优先权日:2015-12-02
标题:Cyclopolymer containing residues of methionine and synthesis and uses thereof
发明人：JAFAR MAZUMDER MOHAMMAD ABU; AL-MUALLEM HASAN ALI; ALI SHAIKH ASROF; Estaitie Mohamad Khalid
权利人:UNIV KING FAHD PET & MINERALS; King Fahd Universoty of Petroleum and Minerals
摘要:Cyclopolymers and N,N-diallyl methionine-based monomers or salts, solvates, tautomers or stereoisomers as corrosion inhibitors. A process for producing the cyclopolymers by Butler cyclopolymerization of the monomers in the presence of sulfur dioxide. In addition, a method for determining a percent inhibition efficiency of metal corrosion for the cyclopolymers and monomers as well as applications and methods for the cyclopolymers as coatings, compositions, and formulations for preventing metal corrosion.

专利号:EP-0946499-B1
优先权日:1996-11-22
标 题 :N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK NORMAN; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions. Said compounds are represented by formula (I), wherein R<1> is selected from the group consisting of: a) alkyl, alkenyl, alkaryl, alkcycloalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic; b) a substituted phenyl group of formula (II), wherein R is alkylene of from 1 to 8 carbon atoms, m is an integer equal to 0 or 1, and c) 1- or 2-naphthyl substituted at the 5, 6, 7 and/or 8 positions, R<2> is selected from the group consisting of hydrogen, alkyl of from 1 to 4 carbon atoms, alkylalkoxy of from 1 to 4 carbon atoms, alkylthioalkoxy of from 1 to 4 carbon atoms; and R<3> and R<3'> are independently selected from the group consisting of: (a) hydrogen, (b) alkyl, (c) -(R<7>)n(W)p, wherein R<7> is an alkylene group, W is selected from the group consisting of (i) formula (A); (ii) heteroaryl; and (iii) N-heterocyclic, and n is an integer equal to 0 or 1, and p is an integer equal to 1 to 3; (d) -CH( phi )CH2C(O)O-Q where Q is selected from the group consisting of alkyl, aryl, heteroaryl and heterocyclic; X' is hydrogen, hydroxy or fluoro; X'' is hydrogen, hydroxy or fluoro, or X' and X'' together form an oxo group, Z is selected from the group consisting of a bond covalently linking R<1> to -CX'X''-, oxygen and sulfur.

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EP-0951464-B1
优先权日:1996-11-22
标题:N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; THORSETT EUGENE D; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; JOHN VARGHESE; FANG LAWRENCE Y; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EP-0951466-B1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; THORSETT EUGENE D; PLEISS MICHAEL A; NISSEN JEFFREY S; NEITZ JEFFREY; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; DROSTE JAMES J; HENRY STEVEN S; MCDANIEL STACEY L; SCOTT WILLIAM L; STUCKY RUSSELL D
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds for Formula (I) wherein the substituents are as defined in the claims which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6262302-B1
优先权日:1996-11-22
标题:N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK N; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.