CAS: 103322-56-1; (S)-Tert-Butyl (1-Cyclohexyl-3-Hydroxypropan-2-yl)Carbamate

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号117160-99-3 (S)-(+)-2-氨基-3-... | CAS号37736-82-6 B°C-L-环己基丙氨酸 | CAS号66605-57-0 N-B°C-L-苯丙氨醇 | CAS号98105-41-0 (S)-2-((叔丁氧基羰基)... | CAS号121056-95-9 (±)-B°C-α-phosp... | CAS号2043-61-0 环己烷甲醛 | CAS号131288-67-0 (S)-2-氨基-3-环己基-1-丙醇 | CAS号27527-05-5 (S)-2-氨基-3-环己基羧酸 | CAS号131288-67-0 (S)-2-氨基-3-环己基-1-丙醇 | CAS号117160-99-3 (S)-(+)-2-氨基-3-...

丁氧羰基--环乙基-丙氨酸-羟基盐酸盐置于borane Tetrahydrofuran,Ice,Glacial Acetic Acid Methyl Alcohol,碳酸氢钠,二氯甲烷,Sodium Sulfate-Iii体系中,用 四氢呋喃 用作溶剂,化学反应 5.0H,反应生成S-(-)-2-N-Boc-3-环己基-1-丙醇
参考文献:Isoindolinone And Pyrrolopyridinone Derivatives As Akt Inhibitors
标题:Isoindolinone And Pyrrolopyridinone Derivatives As Akt Inhibitors
摘要:本发明提供了isoindolinone和pyrrolopyridinone衍生物,以及它们的组合物和使用方法,可以抑制丝氨酸/苏氨酸激酶akt的活性,并且在治疗与akt活性相关的疾病方面很有用,例如癌症和其他疾病.

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-5322963-A
优先权日:1991-02-05
标 题 :Method for preparing α-amino-β, δ-diol derivatives
发明人：SHIBATA SAIZO; SHIRAKAWA EIJI; YAMADA YASUKI; ANDO KOJI; UCHIDA ITSUO
权利人:JAPAN TOBACCO INC
摘要:Intermediate compounds (formula [III]and [IV]) useful as starting materials for the synthesis of amino acid derivatives which have renin inhibitory activity and which are useful as remedies for hypertension are prepared stereoselectively in high yield, without requiring complicated process steps. In this method, by reaction of α-amino aldehyde derivative [I] and compound [II] in the presence of BF 3 .OEt 2 , as shown in the following reaction formula, α-amino-β-hydroxy-δ-ketone derivative [III] is prepared, and furthermore, by reducing it as required, compound [IV] is obtained: ##STR1## (where R 1 is a protective group on the amino group, R 2 is a lower alkyl group which may be branched, and R 4 is a cyclohexyl group or phenyl group).

专利号:US-8129411-B2
优先权日:2005-12-30
标题:Organic compounds
发明人：EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI
权利人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. n The compounds have the formula I′ n nwherein R1, R2, T, R3 and R4 are as defined in the specification.