CAS: 113293-71-3; (6-Aminopyridin-3-yl)Methanol

相似化合物

169280-83-5 36052-24-1 69879-22-7

上下游产品

CAS号3167-49-5 6-氨基烟酸 | CAS号39658-41-8 6-氨基烟酸乙酯 | CAS号36052-24-1 6-氨基烟酸甲酯 | CAS号866561-42-4 acetic acid 6-(... | CAS号329-89-5 6-氨基烟酰胺 | CAS号230617-81-9 2-Pyridinamine,... | CAS号132213-07-1 6-(羟甲基)咪唑并[1,2-a]吡啶 | CAS号132213-03-7 咪唑并<1,2-A>吡啶-6-甲胺 | CAS号322691-19-0 5-((叔丁基二甲基甲硅烷基氧...

6-氨基烟酸甲酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应 16.0H,以2.6 G的收率获得6-氨基-3-吡啶基甲醇
参考文献:Crystal Form,Salt Type Of Substituted 2-Hydro-Pyrazole Derivative And Preparation Method Therefor
标题:Crystal Form,Salt Type Of Substituted 2-Hydro-Pyrazole Derivative And Preparation Method Therefor
摘要:一种取代的2-羟基吡唑衍生物的晶型及其盐型,制备方法,以及该晶型和盐型在制备用于治疗乳腺癌,肺癌等癌症的药物中的应用.

专利信息

专利号:US-2009209554-A1
优先权日:2004-03-24
标题 :Thiazoliums as transketolase inhibitors
发明人：BOYD STEVEN A; CONDROSKI KEVIN R; DE MEESE JASON; GONZALES STEPHEN S; GUNAWARDANA INDRANI W; KAPLAN TOMAS; HUEROU YVAN LE; LYSSIKATOS JOSEPH; ROMOFF TODD T; SULLIVAN FRANCIS X; THOMAS ALLEN
权利人:ARRAY BIOPHARMA INC
摘要:The present invention provides N-3′-pyridyl-methyl or N-2′-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R 1 , R 2 , R 3 , Y, R 5 -R 9 , R a -R d , n and X − are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

专利号:US-7803832-B2
优先权日:2004-03-18
标题 :N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides
发明人：CRITCHER DOUGLAS JAMES; WALSHE NIGEL DEREK ARTHUR; LAURET CHRISTELLE
权利人:PFIZER; PFIZER PROD INC
摘要:The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R 1 -R 5 are described in the description, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.