CAS: 1188-21-2; Ac-Leu-Oh

上下游产品

CAS号61-90-5 L-亮氨酸 | CAS号108-24-7 乙酸酐 | CAS号64896-30-6 2-acetamido-4-m... | CAS号74839-85-3 | CAS号57289-25-5 N-Acetyl-DL-leu... | CAS号99-15-0 N-乙酰-DL-亮氨酸 | CAS号85785-66-6 (1'S,3S)-8-acet... | CAS号18869-43-7 methyl 2-amino-... | CAS号2899-43-6 rac-(R*)-2-Isob... | CAS号99-15-0 N-乙酰-DL-亮氨酸 | CAS号1480-30-4 L-Leucine,N-(2,... | CAS号61-90-5 L-亮氨酸 | CAS号30057-77-3 N-(5-甲基-2-氧代己烷-... | CAS号1026295-98-6 (S)-2-(2-((S)-2... | CAS号32483-15-1 乙酰基-L-亮氨酸甲基酰胺 | CAS号1492-11-1 N-乙酰-L-亮氨酸甲酯 | CAS号26090-94-8 2-acetamido-N,4... | CAS号660847-06-3 (S)-6-乙酰氨基-2-(2... | CAS号40513-34-6 3-氨基-5-甲基-2-己酮

(1'S,3S)-8-Acetoxy-3-(1'-(Acetylamino)-3'-Methylbutyl)-3,4-Dihydro-1-Oxo-1H-2-Benzopyran置于potassium Permanganate,Magnesium Sulfate体系中,用 水 用作溶剂,化学反应 1.5H,反应生成N-乙酰-L-亮氨酸
参考文献:Ai-77S,具有胃肠保护作用的微生物产品的研究.Ai-77S的结构和化学性质
标题:Ai-77S,具有胃肠保护作用的微生物产品的研究.Ai-77S的结构和化学性质
摘要:新型胃保护物质ai-77-B(1)及其类似物ai-77-C(2),D(3),F(4)和g(5)的结构和化学性质.描述了短小芽孢杆菌ai-77.证实1的结构为6-[[1(S)-(3(S),4-二氢-8-羟基-1-氧代-1H-1H-2-苯并吡喃-3-基)-3-甲基丁基].氨基]-4(小号),5(小号)-二羟基-6-氧代-3(小号)-Aminohexanoic酸由x射线与化学研究和组合的结构2,3,4和5通过1的化学合成和光谱分析确定.
Doi:10.1016/s0040-4020(01)83504-3

专利信息

专利号:US-6982350-B2
优先权日:2004-05-19
标 题:Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; GONZALEZ BLANCO ISAAC; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-10456387-B2
优先权日:2011-11-29
标 题:Phacetoperane for treating of attention deficit hyperactivity disorder
发明人：KONOFAL ERIC; FIGADERE BRUNO
权利人:NLS PHARMA AG; NLS PHARMACEUTICS AG
摘要:The invention relates to the treatment of an attention deficit hyperactivity disorder (ADHD) with alpha-phenyl(piperidin-2-yl)methanol, or the pharmaceutically acceptable salts and esters thereof, in particular the acetate derivative, more particularly dextrophacetoperane. The invention additionally provides a method of synthesis of the (S,S) enantiomer of alpha-phenyl(piperidin-2-yl)methanol as well as a method of synthesis of dextrophacetoperane.

专利号:US-8846916-B2
优先权日:2009-05-11
标题:Sitagliptin synthesis
发明人：GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH
权利人:GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH; GENERICS UK LTD
摘要:The present invention relates to novel processes for the preparation of enantiomerically enriched β-amino acid derivatives such as β-amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.

专利号:US-6380416-B2
优先权日:1997-06-13
标题:Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

专利号:WO-2016192694-A1
优先权日:2015-06-05
标 题 :A process for preparing the key intermediate of apremilast, using enzymatic resolution of the racemic amines
发明人：DOUBSKY JAN; KLVANA ROBERT; RICHTER JINDRICH; Lehnert Petr
权利人:ZENTIVA KS
摘要:The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-{2-[l-(3-ethoxy-4- methoxyphenyi)-2-methyisulfonylethyl]-4-acetylaminoisoindolin-l ?3-dione, known as Apremilast. In this synthesis, the amine (S)-l, or its respective salts, are subjected to condensation with 3-acetamidophthalic anhydride 4, providing the desired product 3 (Scheme 1).