CAS: 142-68-7; Oxane

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CAS号6581-66-4 2-甲氧基四氢吡喃 | CAS号97-99-4 四氢糠醇 | CAS号4454-05-1 2-甲氧基-3,4-二氢-2H-吡喃 | CAS号110-87-2 3,4-二氢-2H-吡喃 | CAS号111-29-5 1,5-戊二醇 | CAS号628-76-2 1,5-二氯戊烷 | CAS号80253-92-5 14-(5-hydroxype... | CAS号542-28-9 δ-戊内酯 | CAS号1927-68-0 2-丁氧基四氢-2H-吡喃 | CAS号32767-68-3 2-ISOBUTOXY TET... | CAS号50816-20-1 1-溴-8-(四氢吡喃氧基)辛烷 | CAS号34626-51-2 5-溴-1-戊醇 | CAS号4096-20-2 N-苯基哌啶 | CAS号542-28-9 δ-戊内酯 | CAS号110-94-1 戊二酸 | CAS号694-54-2 四氢-2H-吡喃-2-醇 | CAS号96-47-9 2-甲基四氢呋喃 | CAS号2081-44-9 四氢吡喃-4-醇 | CAS号96-48-0 γ-丁内酯 | CAS号29943-42-8 四氢吡喃酮

1,5-二氯戊烷置于甲基三辛基氯化铵 氢氧化钾,Sodium Formate体系中,化学反应 0.25H,以80%的收率获得四氢吡喃
参考文献:One-Pot Conversion Of Primary Alkyl Chlorides And Dichlorides Into Alcohols,Diols,And Ethers Via Formic Ester Intermediates Under Phase-Transfer Conditions
标题:One-Pot Conversion Of Primary Alkyl Chlorides And Dichlorides Into Alcohols,Diols,And Ethers Via Formic Ester Intermediates Under Phase-Transfer Conditions
摘要:
Doi:10.1055/s-1986-31769

专利信息

专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人：HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

专利号:US-8618279-B2
优先权日:2009-01-15
标 题 :Synthesis of 2′,3′— and 3′,5′—cyclic phosphate mono-and oligonucleotides
发明人：LAIKHTER ANDREI; SRIVASTAVA SURESH CHANDRA; SRIVASTAVA NAVEEN
权利人:LAIKHTER ANDREI; SRIVASTAVA SURESH CHANDRA; SRIVASTAVA NAVEEN; CHEMGENES CORP
摘要:The invention provides a novel method for the chemical synthesis of 2′,3′-cyclic phosphate and phosphorothioate of mono and terminated oligonucleotides synthesis. The invention also provides a novel method of for the chemical synthesis of 2′,3′- and 3′,5′-cyclic phosphate and phosphorothioate mononucleotide nucleotides. The process is based on quick and efficient cyclization of phosphoramidate moiety and neighboring hydroxyl group. The present invention is directed towards the synthesis of high purity DNA and RNAs, specifically to introduce cyclic phosphate at 3′-end of oligonucleotides. Such DNA and RNA's have extensive application in therapeutics, diagnostics, drug design, and selective inhibition of an RNA sequence within cellular environment, in pre-tRNA cleavage and in ribozyme ligation. The 2′,3′-cyclic phosphate nucleosides are involved in a vast number of applications in molecular biology in general and mammalian cells in particular. The invention also envisions providing kits comprising at least one composition disclosed in the present invention.

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-4351767-A
优先权日:1981-06-29
标题 :Synthesis of 24,25-dihydroxycholesterol
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. More particularly, the invention pertains to the synthesis of 24,25-dihydroxycholesterol. It includes intermediate sterols of this synthesis and processes for their preparation.