CAS: 20960-92-3; Thiomorpholine-3-Carboxylic Acid

相似化合物

96612-95-2 128453-98-5 114525-81-4

上下游产品

(3R)-硫代吗啉甲酸 D-Tetrahydro-2H-1,4-Thiazine-3-Carboxylic Acid 65527-54-0
硫代吗啉-3-羧酸乙酯 Ethyl Thiomorpholine-3-Carboxylate 58729-31-0
S-Hydroxyethylcysteine 97170-10-0

S-Hydroxyethylcysteine置于盐酸,三乙胺体系中,用 乙醇 用作溶剂,化学反应 14.5H,反应生成3-硫代吗啉羧酸
参考文献:通过(rs)-2-氨基-3-[(2-氯乙基)亚硫酰基]丙酸盐酸盐的优先结晶,通过光学拆分合成旋光的1,4-噻嗪-3-羧酸.
标题:通过(rs)-2-氨基-3-[(2-氯乙基)亚硫酰基]丙酸盐酸盐的优先结晶,通过光学拆分合成旋光的1,4-噻嗪-3-羧酸.
摘要:通过半胱氨酸的光学拆分,通过优先结晶,从半胱氨酸合成了旋光的1,4-噻嗪-3-羧酸[tca].基于其熔点,溶解度和红外光谱,发现中间体(rs)-2-氨基-3-[(2-氯乙基)硫烷基]丙酸氢氯酸盐[(rs)-Acs•hcl]以团块形式存在光谱.通过优先结晶将(rs)-Acs•hcl光学拆分,得到(R)-和(S)-Acs•hcl.考虑到(rs)-Acs•hcl的溶解度,将由此获得的(R)-和(S)-Acs•hcl从盐酸和2-丙醇的混合物中重结晶,有效地产生光学纯形式的两种对映异构体.然后通过在乙醇中三乙胺存在下环化(R)-和(S)-Acs•hcl分别合成(R)-和(S)-Tca.
Doi:10.1271/bbb.62.2382

专利信息

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:EP-4192512-A1
优先权日:2020-08-06
标题 :Methods for the synthesis of protein-drug conjugates

专利号:WO-2022032175-A1
优先权日:2020-08-06
标题 :Methods for the synthesis of protein-drug conjugates

专利号:CN-107056730-A
优先权日:2017-04-27
标题:A kind of synthesis method and application of impurity isomers of bupropion hydrochloride sustained-release tablets