CAS: 3067-19-4; 2-Acetamido-3-Methylbutanoic Acid

相似化合物

17916-88-0 96-81-1 349-00-8

上下游产品

diethyl 2-N-acetylamino-2-isopropylmalonate 2-acetylamino-3-methyl-crotonic acid acetic anhydride D,L-valine2-methyl-4-iso-propyl-4H-oxazolin-5-one 2-Acetamino-isovaleriansaeure- N-acetyl-DL-valine methyl ester 3-Acetyl-4-isopropyl-5-oxazolidinone

2-氧代-3-甲基丁酸置于乙酸铵,Sodium Cyanoborohydride体系中,用 甲醇 作为反应溶剂,化学反应 46.0H,反应生成 N-乙酰-Dl-缬氨酸
参考文献:使用penicilliumchrysogenum合成[3-3H,U-14C]-L-缬氨酸并将其掺入青霉素v中
标题:使用penicilliumchrysogenum合成[3-3H,U-14C]-L-缬氨酸并将其掺入青霉素v中
摘要:通过用 Naoh-Hto 交换二甲基丙酮酸合成标题化合物,然后在甲醇溶剂中使用氰基硼氢化物进行还原胺化,拆分 N-氯乙酰衍生物,并与 [u-14C]-L-缬氨酸混合.化合物的降解表明 94.5% 的氚连接在 C3 上,5.5% 位于甲基上.将此双标记缬氨酸掺入以二苄胺盐形式纯化的青霉素 V 中,最初存在于 C3 的氚损失了 100.7%.市售的 [2,3-3H,U-14C]-L-缬氨酸被发现在甲基上含有 12% 的氚,也被掺入青霉素 V 中,纯化为其甲酯.去除与该酯的 C3 相连的氢的降解表明该位置不存在氚.所以,
DOI:10.1139/v82-055

专利信息

专利号:US-6982350-B2
优先权日:2004-05-19
标 题:Process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; GONZALEZ BLANCO ISAAC; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

专利号:US-2005261376-A1
优先权日:2004-05-19
标 题:Process for the synthesis of (is)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

专利号:US-2023046065-A1
优先权日:2019-11-25
标题 :MERGING C(sp3)-H ACTIVATION WITH DNA-ENCODING
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Palladium-catalyzed C(sp3)—H arylation of aliphatic carboxylic acids, amides and ketones with BNA-encoded aryl iodides in water is disclosed, Furthermore, sequential C—H arylation chemistry enabled the on-DNA synthesis of structurally-diverse scaffolds containing enriched C(sp3) character, chiral centers, cyclopropane, cyclobutane, and heterocycles. That new chemistry permits preparation of a DNA—encoded library (BEL) technology that can dramatically expedite hit identification in drug discovery owing to its ability to perform protein affinity selection with millions or billions of molecules in a single experiment. The sequential functionalization of multiple C—H bonds provides an unique avenue for creating diversity and complexity from simple starting materials. The use of water as solvent, the presence of DMA, and the extremely low concentration of DMA-encoded coupling partners (0.001 M) have previously hampered the development DMA-encoded C(sp3)—H activation reactions, but many of those hurdles have now been overcome.

专利号:US-9676676-B2
优先权日:2014-07-02
标题 :Selective olefin metathesis with cyclometalated ruthenium complexes
发明人：HARTUNG JR JOHN; QUIGLEY BRENDAN L; DORNAN PETER K; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

专利号:US-9556221-B2
优先权日:2014-06-20
标题:N-acetyl amino acid ESTER derivatives of betulin and preparation method thereof
发明人：WANG YANG; ZHANG SHENG; DING WEIMING; YU TAO; YAN XIUFENG
权利人:UNIV NORTHEAST FORESTRY
摘要:The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the presence of an alkaline substance, a catalyst and a racemization-inhibitor, the carboxyl group of N-acetyl amino acid is activated by a coupling agent; and then the activated N-acetyl amino acid is reacted with betulin via esterification reaction to obtain the N-acetyl amino acid ester derivative of betulin. The present invention provided a simple synthesis method to synthesize the N-acetyl amino acid ester derivatives of betulin by using betulin as a precursor compound and modifying the molecular structure of betulin. Such structural modification of betulin significantly enhances the anti-tumor activity of the betulin derivatives and therefore has important values.

专利号:BR-112019014061-A2
优先权日:2017-01-23
标 题 :compounds of formula i, intermediates b, intermediates c, intermediates ii and intermediates d, composition, use, method to combat phytopathogenic fungi, seed and process for the synthesis of the compounds of formula i