CAS: 41604-19-7; 4-Bromo-2-Fluoro-1,1'-Biphenyl

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CAS号497-19-8 纯碱 | CAS号105931-73-5 1-溴-3-氟-4-碘苯 | CAS号98-80-6 苯硼酸 | CAS号367-24-8 4-溴-2-氟苯胺 | CAS号7439-89-6 铁粉 | CAS号71-43-2 苯 | CAS号321-60-8 2-氟联苯 | CAS号63444-55-3 4-ethenyl-2-flu... | CAS号5104-49-4 氟比洛芬 | CAS号57592-43-5 2-氟联苯基-4-甲醛 | CAS号137045-30-8 2-氟联苯基-4-羧酸 | CAS号269410-15-3 2-氟-4-联苯硼酸频哪醇酯 | CAS号116831-33-5 4-BROMO-2-FLUOR... | CAS号113770-42-6 2′-氟-1,1′:4′,1′′-三联苯 | CAS号116831-22-2 1-(4'-Bromo-2'-... | CAS号76699-46-2 2-fluoro-4-biph...

4-溴-2-氟苯胺 以69的收率获得产物4-溴-2-氟联苯
参考文献:一种氟比洛芬酯的制备方法
标题:一种氟比洛芬酯的制备方法
摘要:本发明涉及一种氟比洛芬酯的制备方法,该方法包括将邻氟苯胺在1,3-二溴-5,5-二甲基海因的作用下的到4-溴-2-氟苯胺,其在催化剂及亚硝酸钠的作用下,与苯缩合反应生成4-溴-2-氟联苯,其在催化剂的作用下与2-溴丙酸钠经格氏反应再经酸化反应反应生成2-(2-氟-4-联苯基)丙酸,其与1-氯乙酸乙基酯缩合反应生成目标化合物氟比洛芬酯,氟比洛芬酯粗品经过分子蒸馏,得到氟比洛芬酯终产品.

专利信息

专利号:US-5254776-A
优先权日:1992-07-17
标 题:Synthesis of bromobiphenyls
发明人：LANG JOHN F; GURUSAMY NARAYANASAMY
权利人:MALLINCKRODT SPEC CHEM
摘要:Bromobiphenyls (such as 2-fluoro-4-bromobiphenyl) are synthesized by reacting together a phenylboronic acid (such as phenylboronic acid) and a bromoiodobenzene (such as 2-fluoro-4-bromoiodobenzene). The reaction generally takes place with the aid of a catalyst (such as palladium in a zero valance state) and an inert solvent (such as fluorobenzene). Control of temperature is very important to obtain both an acceptable reaction rate and an acceptable level of terphenyl byproduct.

专利号:WO-2024185814-A1
优先权日:2023-03-06
标题:Method for producing aryl compound containing tritylsulfanyl group
发明人：OKAZOE TAKASHI; NOZAKI KYOKO; GATZENMEIER Tim; LIU YUE
权利人:AGC INC; UNIV TOKYO
摘要:The present invention provides: a substrate for achieving the highly efficient synthesis of an aryl compound containing a tritylsulfanyl group; a method for producing a compound containing an SF 5 group using the substrate; and others. The present invention is a method for producing an aryl compound containing a tritylsulfanyl group, the method comprising thiotritylating a halogenated aryl compound represented by general formula (1) [wherein A 1 represents an aryl group that may have a substituent or a heteroaryl group that may have a substituent; and X represents a halogen atom] using [(triphenylmethyl)sulfanyl]potassium or [(triphenylmethyl)sulfanyl]sodium to produce an aryl compound containing a tritylsulfanyl group, the aryl compound being represented by general formula (2) [wherein A 1 is the same as A 1 in general formula (1); and Ph represents a phenyl group].

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:US-6017926-A
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：ASKEW BEN C; COLEMAN PAUL J; DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; MEISSNER ROBERT S; PATANE MICHAEL A; WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.

专利号:US-9550757-B2
优先权日:2010-03-05
标题:Nuclear transport modulators and uses thereof
发明人：SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

专利号:CN-102030651-A
优先权日:2009-09-28
标题:Synthesis method of 2-fluo-4-bromobiphenyl ethyl formate