专利号:US-6486169-B1 优先权日:2002-02-19 标题:Botanical drug for treatment and prevention of alzhimer's disease 发明人:LIU YAGUANG 摘要:The present invention related to safe botanical drug for treatment and prevention of Alzheimer's disease. Specifically, this invention proves a safe botanical drug, Huperzine (HUE) and Clausenamide (CLE) and their preparation.HUE has the following pharmaceutical functions: inhibiting acetylcholinesterase (CAT), increasing memory, decreasing Alzheimer amyloid protein, increasing RNA and protein synthesis of brain, increasing calcium in brain, decreasing superoxide anion.CLE has the following pharmaceutical functions: increasing memory, decreasing Alzheimer amyloid protein, increasing RNA and protein synthesis of brain, increasing calcium in brain, decreasing superoxide anion, increasing long-term potentiation and increasing dopanmine (DA). It is important that HUE combined with CLE have stronger function as mentioned above.
专利号:EP-3103803-B1 优先权日:2008-10-27 标 题 :Intermediates for the synthesis of mtor kinase inhibitors
专利号:EP-3660020-A1 优先权日:2008-10-27 标题 :Process for the synthesis of mtor kinase inhibitors
专利号:ES-2794012-T3 优先权日:2008-10-27 标题 :Intermediaries for the synthesis of mTOR kinase inhibitors
专利号:US-2013131310-A1 优先权日:2010-07-28 标题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto 发明人:KANE JOHN; LANCASTER THOMAS M; ZION TODD C 权利人:KANE JOHN; LANCASTER THOMAS M; ZION TODD C 摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein each of X, Alk, and W are as defined and described herein.
专利号:EP-3103803-A1 优先权日:2008-10-27 标 题 :Intermediates for the synthesis of mtor kinase inhibitors
1: Abad-Gurumeta A, Ripollés-Melchor J, Casans-Francés R, Espinosa A, Martínez-Hurtado E, Fernández-Pérez C, Ramírez JM, López-Timoneda F, Calvo-Vecino JM; Evidence Anaesthesia Review Group. A systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade. Anaesthesia. 2015 Dec;70(12):1441-52. doi: 10.1111/anae.13277. Review. doi: 10.4103/1658-354X.146319. Review. 3: Liu SH, Tseng CY, Lin CC. Is neostigmine effective in severe pufferfish-associated tetrodotoxin poisoning? Clin Toxicol (Phila). 2015 Jan;53(1):13-21. doi: 10.3109/15563650.2014.980581. Epub 2014 Nov 20. Review. doi: 10.1016/j.amsu.2014.04.002. eCollection 2014 Sep. Review. 5: Yang L, Yang D, Li Q, Zuo Y, Lu D. Neostigmine for reversal of neuromuscular block in paediatric patients. Cochrane Database Syst Rev. 2014 May 5;5:CD010110. doi: 10.1002/14651858.CD010110.pub2. Review. doi: 10.1345/aph.1Q515. Epub 2012 Feb 28. Review. doi: 10.1016/j.ijsu.2012.08.008. Epub 2012 Sep 14. Review. doi: 10.1093/bja/aeq269. Epub 2010 Oct 8. Review.
合成参考文献
参考文献:10.1007/s12630-011-9554-y 摘要:Le Corre F, Nejmeddine S, Fatahine C, Tayar C, Marty J, Plaud B. Recurarization after sugammadex reversal in an obese patient. Journal canadien d'anesthésie. 2011 Jul 13;58(10):944. doi: 10.1007/s12630-011-9554-y. 参考文献:10.1007/s00540-011-1190-8 摘要:El Tahan MR. Effects of aminophylline on cognitive recovery after sevoflurane anesthesia. J Anesth. 2011 Oct;25(5):648–56. doi: 10.1007/s00540-011-1190-8. 参考文献:10.1007/s00360-011-0602-2 摘要:Abramochkin DV, Borodinova AA, Rosenshtraukh LV. Effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. Journal of Comparative Physiology B. 2011 Jul 15;182(1):101–8. doi: 10.1007/s00360-011-0602-2.