CAS: 65202-50-8; Methyl 6-Chloropyridazine-3-Carboxylate

相似化合物

5096-73-1 303085-53-2 1011487-94-7

上下游产品

CAS号6531-04-0 6-chloropyridaz... | CAS号63001-30-9 6-氧代-1,6-二氢哒嗪-3-甲酸甲酯 | CAS号5096-73-1 6-氯哒嗪-3-羧酸 | CAS号124-41-4 甲醇钠 | CAS号67-56-1 甲醇 | CAS号142054-67-9 6-(丁基氨基)-3-哒嗪羧酸甲酯 | CAS号142054-74-8 6-乙氧基哒嗪-3-羧酸 | CAS号142674-93-9 6-[(苯基甲基)氨基]-3-哒嗪羧胺 | CAS号66346-83-6 6-氯哒嗪-3-甲酰胺 | CAS号1011487-94-7 (6-氯哒嗪-3-基)甲醇 | CAS号142054-70-4 6-[(苯基甲基)氨基]-3-... | CAS号89967-27-1 methyl 6-pent-1... | CAS号89967-28-2 methyl 6-pentyl...

Methyl 6-Oxo-1,6-Dihydropyridazine-3-Carboxylate,Hydrochloride置于三氯氧磷体系中,化学反应 2.0H,反应生成 6-氯哒嗪-3-甲酸甲酯
参考文献:3 (3-Pyrimidin-2-Ylbenzyl)-1,2,4-Triazolo[4,3-B]Pyridazine Derivatives
标题:3 (3-Pyrimidin-2-Ylbenzyl)-1,2,4-Triazolo[4,3-B]Pyridazine Derivatives
摘要:式(I)中的化合物,其中r1,R2,R3,R3',R4具有权利要求1中指示的含义,是酪氨酸激酶的抑制剂,特别是met激酶,并可用于治疗肿瘤等疾病.

专利信息

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:WO-0107416-A1
优先权日:1999-07-28
标题 :Method of producing pyridazine carboxylic acid derivatives
发明人：BESSARD YVES; CRETTAZ ROGER; EGGEL MICHAEL
权利人:LONZA AG; BESSARD YVES; CRETTAZ ROGER; EGGEL MICHAEL
摘要:The invention relates to a method of producing pyridazine carboxylic acid derivatives of the general formulae (Ia) or (Ib), wherein R<1> represents a group of the formula -OR<3> or -NR<4>R<5>, R<2> represents hydrogen, chlorine, a group of the formula -OR<6> or a group of the formula -NR<7>R<8>, R<3> represents C1-10 alkyl, C3-8 cycloalkyl or aryl-C1-4-alkyl, R<4> represents C1-10 alkyl, C3-8 cycloalkyl, optionally substituted aryl or aryl-C1-4-alkyl, R<5> represents hydrogen, C1-10 alkyl, C3-8 cycloalkyl, optionally substituted aryl or aryl-C1-4-alkyl and R<6> represents C1-10 alkyl, C3-8 cycloalkyl, aryl-C1-4-alkyl or an optionally substituted aromatic or heteroaromatic rest and R<7> and R<8> represent independently C1-10 alkyl, C3-8 cycloalkyl or aryl-C1-4-alkyl or together with the nitrogen atom form a saturated or aromatic heterocyclic ring. The inventive derivatives are obtained by reacting the corresponding 3-chloropyridazines or 3,6-dichloropyridazine with carbon monoxide and alcohols or amines H-R<1> in the presence of palladium-phosphin complexes and bases. The pyridazine carboxylic acid derivatives (Ia, Ib) are the intermediates for the synthesis of pharmaceutically active substances.

专利号:US-2009118296-A1
优先权日:2005-07-20
标 题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
发明人：BLACK CAMERON; DESCHENES DENIS; GAGNON MARC; LACHANCE NICOLAS; LEBLANC YVES; LEGER SERGE; LI CHUN SING; OBALLA RENATA M
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.

专利号:US-2009170828-A1
优先权日:2006-06-12
标题:Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
发明人：ISABEL ELISE; OBALLA RENATA; POWELL DAVID; ROBICHAUD JOEL
权利人:ISABEL ELISE; OBALLA RENATA; POWELL DAVID; ROBICHAUD JOEL
摘要:Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I)

专利号:US-7799787-B2
优先权日:2005-12-20
标 题 :Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：DESCHENES DENIS; FORTIN REJEAN; LI CHUN SING; OBALLA RENATA M; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.

专利号:WO-2023280237-A1
优先权日:2021-07-07
标题 :Synthesis and application of phosphatase degrader