CAS: 705-29-3; 1-(Chloromethyl)-3-(Trifluoromethyl)Benzene

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CAS号349-75-7 3-(三氟甲基)苄醇 | CAS号454-89-7 间三氟甲基苯甲醛 | CAS号454-92-2 3-三氟甲基苯甲酸 | CAS号455-01-6 3-(三氟甲基)苯乙醇 | CAS号51421-34-2 (3-三氟甲基苄基)-肼 | CAS号454-89-7 间三氟甲基苯甲醛 | CAS号349-75-7 3-(三氟甲基)苄醇 | CAS号72390-22-8 1-(trifluoromet... | CAS号67646-72-4 4-(3-trifluorom... | CAS号351-35-9 3-(三氟甲基)苯乙酸 | CAS号55513-16-1 1-[3-(三氟甲基)苄基]哌嗪

3-三氟甲基苯甲醇置于氯化亚砜体系中,用 甲苯 作为反应溶剂,化学反应 0.08H,反应生成 1-氯甲基-3-三氟甲基苯
参考文献:Piritrexim的2,4-二氨基6-(芳基甲基)-5,6,7,8-四氢喹唑啉类似物的合成及其抗寄生虫和抗肿瘤活性.
标题:Piritrexim的2,4-二氨基6-(芳基甲基)-5,6,7,8-四氢喹唑啉类似物的合成及其抗寄生虫和抗肿瘤活性.
摘要:合成了19种先前未描述的2,4-二氨基-6-(芳基甲基)-5,6,7,8-四氢喹唑啉(5A-M,10-12)作为更大努力的一部分,以评估亲脂性二氢叶酸还原酶的治疗潜力(dhfr)抑制剂,可防止艾滋病的机会性感染.将适当取代的(芳基甲基)三苯基膦与4,4-亚乙基二氧环己酮缩合,然后加氢(h2 / Pd-C)和酸解反应,得到相应的4-(芳基甲基)环己酮,然后将其与氰基胍缩合形成四氢喹唑啉.还通过一步法从市售的4-烷基环己酮一步制备了三种简单的2,4-二氨基-6-烷基-5,6,7,8-四氢喹唑啉模型化合物(9A-C).针对大鼠肝脏dhfr,卡氏肺孢子虫dhfr,进行了弓形虫双功能dhfr-Ts酶的比较,比较了ic50(rat)/ Ic50(p.carinii)和ic50(rat)/ Ic50(t.gondii)的选择性比.carinii Dhfr的三种最有效抑制剂是2,5-二甲氧基苄基(5J),3,4-二甲氧基苄基(5K)和3
DOI:10.1021/jm980572I

专利信息

专利号:EP-1326851-B1
优先权日:2000-10-13
标 题 :Substituted dipeptides as growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for usein the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-7781470-B2
优先权日:1999-09-13
标题:Aminodicarboxylic acid derivatives having pharmaceutical properties
发明人：ALONSO-ALIJA CRISTINA; HEIL MARKUS; FLUBACHER DIETMAR; NAAB PAUL; PERNERSTORFER JOSEF; STASCH JOHANNES-PETER; WUNDER FRANK; DEMBOWSKY KLAUS; PERZBORN ELIZABETH; STAHL ELKE
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, n nwherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.

专利号:CN-102911126-A
优先权日:2012-11-20
标题 :Synthesis of 2-arylquinazolinones from benzyl halides and anthranilamides

专利号:US-7125840-B2
优先权日:2001-10-09
标题:Substituted dipeptides as growth hormone secretagogues
发明人：DODGE JEFFREY ALAN; EVERS BRITTA; JUNGHEIM LOUIS NICKOLAUS; MUEHL BRIAN STEPHEN; RUEHTER GERD; THRASHER KENNETH JEFF
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:CN-113200815-B
优先权日:2021-04-29
标题 :A method for continuous flow synthesis of m-trifluoromethylbenzyl chloride

专利号:US-2008176857-A1
优先权日:2005-03-25
标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.