CAS: 140-75-0; (4-Fluorophenyl)Methanamine

相似化合物

659-41-6 824-75-9 100-82-3

上下游产品

CAS号459-57-4 对氟苯甲醛 | CAS号1194-02-1 对氟苯腈 | CAS号352-11-4 对氟氯苄 | CAS号459-23-4 4-氟苯甲醛肟 | CAS号459-56-3 对氟苯甲醇 | CAS号371-40-4 4-氟苯胺 | CAS号74-88-4 碘甲烷 | CAS号459-46-1 对氟溴苄 | CAS号824-75-9 4-氟苯甲酰胺 | CAS号111043-24-4 1-chloro-3-[(4-... | CAS号33400-49-6 2-氨基-3-硝基-6-(4-... | CAS号55096-88-3 N-苄基-4-氟苄基胺 | CAS号148890-53-3 4-氟苄基异氰化物 | CAS号405-66-3 N-甲基-4-氟苄胺 | CAS号1194-02-1 对氟苯腈 | CAS号459-57-4 对氟苯甲醛 | CAS号1978-88-7 N-(4-Chlorophen... | CAS号2714-80-9 N'-(4-Fluoro-be...

对氟苯腈置于dichlorocobalt;2-Diphenylphosphanyl-N-(2-Diphenylphosphanylethyl)Ethanamine,氢气,三乙基硼氢化钠体系中,用 1,4-二氧六环 用作溶剂,80.0 °C,5.0 Mpa 条件下,反应 6.0H,以99%的收率获得对氟苄胺
参考文献:钴夹钳配合物,用于将腈催化还原成伯胺†
标题:钴夹钳配合物,用于将腈催化还原成伯胺†
摘要:各种钴夹钳型配合物1-6用于腈腈催化加氢成胺.在这些催化剂中,催化剂4是最有效的,可以中等至极好的收率还原芳族腈和脂族腈.
Doi:10.1039/c9Cy00225A

专利信息

专利号:US-2021220331-A1
优先权日:2016-05-03
标题:Inhibitors of ires-mediated protein synthesis
发明人：GERA JOSEPH F; LICHTENSTEIN ALAN; JUNG MICHAEL E; LEE JIHYE; HOLMES BRENT; BENAVIDES-SERRATO ANGELICA
权利人:UNIV CALIFORNIA; THE UNITED STATE GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2013296346-A1
优先权日:2010-11-23
标题 :Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions
发明人：RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO
权利人:RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO; FAES FARMA SA
摘要:The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.

专利号:US-6228988-B1
优先权日:1995-02-24
标题:Synthesis of hydroxamic acid derivatives
发明人：FLOYD CHRISTOPHER DAVID; LEWIS CHRISTOPHER NORMAN
权利人:BRITISH BIOTECH PHARM
摘要:The present invention describes processes for preparing desired synthetic products that comprise a covalently bonded hydroxamic acid group -CONHOH by forming a mixture of a liquid reaction medium and a solid phase reaction product that carries a plurality of moieties of formula (A1) or (B1):where X is a residual, non-hydroxamate partial structure of the desired synthetic product, P1 is hydrogen or an amino-protecting group, P2 is hydrogen or a hydroxyl protecting group, and the bond designated (a) covalently links the moieties (A1) or (B1) to the residue of a solid substrate; by cleaving the bond designated (a) in the resultant mixture; and by separating the resultant liquid reaction phase from the resultant reaction solids to recover the desired synthetic product.

专利号:US-2024051897-A1
优先权日:2022-07-26
标题:Synthesis of complex 15n-labeled molecules
发明人：DORSHEIMER JULIA; ROVIS TOMISLAV
权利人:UNIV COLUMBIA
摘要:Methods for conversion of a broad range of amines to their 15N isotopic counterparts and the compounds produced thereby.

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.