CAS: 16106-38-0; 4-Aminobenzoyl Chloride

该化合物是一种有机化合物,其特点是有矿和丙基氯化物功能组,其典型特征是无色的黄色淡液,其发泡的气味不显眼;该化合物以其反应性闻名,特别是由于乙基氯组碳碳碳的电益性,使它成为有机合成的有用中间体;它可以参与各种化学反应,包括杂交和恐吓,允许将苯并酰基组引入其他分子中;氨基组的存在还具有基本特性,使其能形成酸盐;然而,苯并基氯化,4-氨基-对水具有敏感性,在水中可进行水解,释放盐酸;在处理该化合物时,必须采取安全防范措施,因为它可能对皮肤,眼睛和呼吸系统造成腐蚀和刺激.

英文名称4-Aminobenzoyl Chloride
中文名称4-氨基苯甲酰氯
IUPAC名称4-Aminobenzoyl chloride
其它别名Benzoyl Chloride, 4-Amino- (9Ci); Benzoyl Chloride, 4-Amino-; P-Aminobenzoyl Chloride
CAS编号16106-38-0
MFCD编号:MFCD03426570
分子式:C7H6ClNO
分子量:155.58
产品CID: 812630
产品分类有机原料 → 羧酸类化合物及衍生物 → 羧酸酰卤化物

相似结构搜索
产品信息参考;
InChIKey: JCQPONUUPNAEGZ-UHFFFAOYSA-N
InChI=1S/C7H6ClNO/c8-7(10)5-1-3-6(9)4-2-5/h1-4H,9H2…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数1.0

MSDS等安全信息

警示词Danger
危险描述H302-H314-
防范说明P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P363-P403+P233-P501-

上下游产品

合成工艺路线路线简述

对氨基苯甲酸置于氯化亚砜体系中,化学反应 0.5H,反应生成4-氨基苯甲酰氯
参考文献:Synthesis And Pharmacological Evaluation Of Novel 1-(2-(Benzoyl-Substituted-2-Phenyl-1H-Indol-5-Carbony) Hydrazinyloxy) Vinyl Nitrate Derivatives As Potent Non-Ulcerogenic,Analgesic And Anti-Inflammatory Agents
标题:Synthesis And Pharmacological Evaluation Of Novel 1-(2-(Benzoyl-Substituted-2-Phenyl-1H-Indol-5-Carbony) Hydrazinyloxy) Vinyl Nitrate Derivatives As Potent Non-Ulcerogenic,Analgesic And Anti-Inflammatory Agents
摘要:六种1-(2-(苯甲酰基(取代)-2-苯基-1H-吲哚-5-羰基)酰肼氧基)乙烯硝酸盐衍生物被合成并在体内测试了其抗炎,镇痛和致溃疡的性质.合成的化合物显示出显著的抗炎活性,与双氯芬酸钠在角叉菜胶诱导的大鼠足跖水肿试验中的效果相当,并且所有化合物均在与乙酸诱导的扭体镇痛模型中与双氯芬酸钠具有同等效能.在六种衍生物中,有两种衍生物被发现在大鼠胃标本中不产生溃疡;硝基氧化物似乎有助于其卓越的安全性,这支持了多种内源性胃肠道防御机制,包括增加粘液和碳酸氢盐分泌,增加粘膜血流量,以及通过抑制促炎细胞的激活来保护胃肠道粘膜.这些特性与no-吲哚美辛的保护机制相符.
Doi:10.2174/1573406411006040211

海关参考信息

2912110000-甲醛
2912210000-苯甲醛
2903110000-一氯甲烷及氯乙烷
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8987503-B2
优先权日:2013-04-30
标题 :Process for the synthesis of aminaphtone
发明人：BALDACCI MASSIMO; ROBERTI MARINELLA
权利人:BALDACCI LAB SPA
摘要:The present invention concerns a new process for the synthesis of aminaphtone, which makes use of non-toxic solvents and reagents, under mild reaction and temperature conditions. The aminaphtone obtained with the method of the present invention also has a purity of at least 98% in weight. The method comprises the following steps: a) epoxidating menadione 1 to provide epoxide 2, b) acidifying epoxide 2 to provide hydroxynaphthoquinone 3, c) esterifying between hydroxynaphthoquinone 3 and 4-aminobenzoyl chloride to obtain compound 4, and d) reducing compound 4 in the presence of a reducing agent in water to obtain aminaphtone.

专利号:US-2014323747-A1
优先权日:2013-04-30
标题:Process for the synthesis of aminaphtone

专利号:BR-102014010331-A2
优先权日:2013-04-30
标题 :PROCESS FOR THE SYNTHESIS OF AMINAFTONE

专利号:EP-2799426-A1
优先权日:2013-04-30
标题:New process for the synthesis of aminaphtone

专利号:EP-2799426-B1
优先权日:2013-04-30
标题 :New process for the synthesis of aminaphtone