CAS: 182482-25-3; 2,4,6-Trifluorophenylboronic Acid

上下游产品

CAS号2367-76-2 1-溴-2,4,6-三氟苯 | CAS号121-43-7 硼酸三甲酯 | CAS号372-38-3 1,3,5-三氟苯 | CAS号363-72-4 五氟苯 | CAS号1206164-33-1 2,4,6-trifluoro... | CAS号49602-47-3 1-methoxy-2-(4-...

2,4,6-Trifluorophenyl Trifluoroborate 以 Phosphate Buffer 用作溶剂,化学反应生成2,4,6-三氟苯硼酸
参考文献:Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki−miyaura Coupling And The Design Of Stable 18F-Labeled Aryltrifluoroborates For Use In Pet Imaging
标题:Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki−miyaura Coupling And The Design Of Stable 18F-Labeled Aryltrifluoroborates For Use In Pet Imaging
摘要:Whereas Electron Withdrawing Substituents Retard The Rate Of Aryltrifluoroborate Solvolysis,Electron-Donating Groups Enhance It. Herein Is Presented A Hammett Analysis Of The Solvolytic Lability Of Aryltrifluoroborates Where Log(K(Solv)) Values Correlate To Sigma Values With A Rho Value Of Approximately-1. This Work Provides A Predictable Rubric For Tuning The Reactivity Of Boron For Several Uses Including F-18-Labeled Pet Reagents And Has Mechanistic Implications For Arbf3-Enhanced Ligandless Metal-Mediated Cross Coupling Reactions With Aryltrifluoroborates.
Doi:10.1021/jo800681D

专利信息

专利号:WO-2025006693-A1
优先权日:2023-06-30
标 题 :Cannabidiol-like compounds and methods for the selective preparation of the same
发明人：CHITTIBOYINA AMAR G; CHATTERJEE SHAMBA; PANDEY PANKAJ; KHAN IKHLAS A
权利人:UNIV MISSISSIPPI
摘要:In one aspect, the disclosure relates to new cannabidiol (CBD) analogs produced from allylic monoterpene alcohols and substituted resorcinols in the presence of aryl boronic acids, efficient and mild synthetic methods of making the new CBD analogs, and improved methods of making known CBD analogs. In one aspect, the methods produce low amounts of tetrahydrocannabinol (THC)-like compounds, low amounts of abnormal cannabidiol (abn-CBD) analogs, and higher amounts of CBD analogs, greatly simplifying purification. The methods can be tailored further to produce low amounts of CBD analogs and higher amounts abn-CBD analogs. In the disclosed methods, synthesis parameters can be varied in order to selectively produce a desired normal or abnormal regioisomer.

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.