CAS: 287383-59-9; 6-(1,3-Dioxo-1H-Benzo[de]Isoquinolin-2(3H)-yl)-N-Hydroxyhexanamide

该化合物是合成有机化合物,其结构复杂,包括一种含有二氧化物混合物混合物结合的苯并[de]isquinline核心体,该化合物的特点是氢氧xxnamide的侧链,有助于其潜在的生物活动. 羟基集团的存在表明,它可能从事氢结合,提高极地溶剂的溶性.二氧基组表明潜在的再活动,可能允许与各种生物目标相互作用.其独特的结构结构可能具有特定的药用特性.该化合物的稳定性,溶性以及再活性可能受到诸如pH和温度等环境因素的影响.虽然可能不容易获得详细的生物活动数据,但这种性质的化合物往往因其在药物开发中的潜在作用而被探索,特别是在针对特定酶或受体的特性及其结构复杂性方面.

结构式图片

上下游产品

1,8-Naphthalic anhydride 6-aminohexanoic acid

合成工艺路线路线简述

    1,8-萘二甲酸酐置于1-羟基苯并三唑,对甲苯磺酸,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,三乙胺体系中,用 乙醇,二氯甲烷,水,异丙醇 用作溶剂,化学反应 40.75H,反应生成Scriptaid抑制剂
    参考文献:A Fluorescent Histone Deacetylase (Hdac) Inhibitor For Cellular Imaging
    标题:A Fluorescent Histone Deacetylase (Hdac) Inhibitor For Cellular Imaging
    摘要:荧光4Ms具有与scriptaid相当的hdac和抗癌活性,并且可以实现细胞快速摄取和细胞质定位的可视化.
    Doi:10.1039/c5Cc02059J

    海关参考信息

    专利信息


    专利号:US-11594226-B2
    优先权日:2020-12-22
    标题 :Automatic synthesis of translated speech using speaker-specific phonemes
    发明人:LIU SU; LIANG YANG; ANGLIN DEBBIE; YANG FAN
    权利人:IBM
    摘要:An embodiment includes converting an original audio signal to an original text string, the original audio signal being from a recording of the original text string spoken by a specific person in a source language. The embodiment generates a translated text string by translating the original text string from the source language to a target language, including translation of a word from the source language to a target language. The embodiment assembles a standard phoneme sequence from a set of standard phonemes, where the standard phoneme sequence includes a standard pronunciation of the translated word. The embodiment also associates a custom phoneme with a standard phoneme of the standard phoneme sequence, where the custom phoneme includes the specific person's pronunciation of a sound in the translated word. The embodiment synthesizes the translated text string to a translated audio signal including the translated word pronounced using the custom phoneme.

    专利号:US-8802380-B2
    优先权日:2007-06-04
    标 题 :Method for testing or screening protein synthesis inhibitors
    发明人:DREYFUSS GIDEON; KASIM MUMTAZ
    权利人:DREYFUSS GIDEON; KASIM MUMTAZ; UNIV PENNSYLVANIA
    摘要:This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus. Additionally, the invention provides a kit and a system for screening protein synthesis inhibitors in a cell.

    专利号:US-2022199086-A1
    优先权日:2020-12-22
    标题:Automatic synthesis of translated speech using speaker-specific phonemes

    专利号:AU-2007300627-A1
    优先权日:2006-09-22
    标题:Method of treatment using fatty acid synthesis inhibitors

    专利号:AU-2007300627-B2
    优先权日:2006-09-22
    标题 :Method of treatment using fatty acid synthesis inhibitors

    专利号:JP-2010504329-A
    优先权日:2006-09-22
    标题:Methods of treatment using fatty acid synthesis inhibitors
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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Liang S, Zhao MH, Choi JW, Kim NH, Cui XS. Scriptaid Treatment Decreases DNA Methyltransferase 1 Expression by Induction of MicroRNA-152 Expression in Porcine Somatic Cell Nuclear Transfer Embryos. PLoS One. 2015 Aug 11;10(8):e0134567. doi: 10.1371/journal.pone.0134567. eCollection 2015.
    2: Sun H, Lu F, Zhu P, Liu X, Tian M, Luo C, Ruan Q, Ruan Z, Liu Q, Jiang J, Wei Y, Shi D. Effects of Scriptaid on the Histone Acetylation, DNA Methylation and Development of Buffalo Somatic Cell Nuclear Transfer Embryos. Cell Reprogram. 2015 Oct;17(5):404-14. doi: 10.1089/cell.2014.0084. Epub 2015 Jun 2. doi: 10.1371/journal.pone.0127058. eCollection 2015.
    4: Sun H, Lu F, Liu X, Tian M, Ruan Z, Zhu P, Ruan Q, Jiang J, Shi D. Effects of scriptaid on the histone acetylation of buffalo oocytes and their ability to support the development of somatic cell nuclear transfer embryos. Theriogenology. 2015 Apr 15;83(7):1219-25. doi: 10.1016/j.theriogenology.2015.01.003. Epub 2015 Jan 8. doi: 10.1002/mrd.22287. Epub 2013 Dec 17. doi: 10.1016/j.theriogenology.2013.09.032. Epub 2013 Oct 6. doi: 10.1089/cell.2012.0092. Epub 2013 Jun 22. doi: 10.1016/j.theriogenology.2013.03.003. Epub 2013 Apr 6.

    合成参考文献


    参考文献:10.1095/biolreprod.110.089474
    摘要:Bui HT, Seo HJ, Park MR, Park JY, Thuan NV, Wakayama T, Kim JH. Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. Biol Reprod. 2011 Nov;85(5):1048–56. doi: 10.1095/biolreprod.110.089474.
    参考文献:10.1089/cell.2011.0024
    摘要:Wang LJ, Zhang H, Wang YS, Xu WB, Xiong XR, Li YY, Su JM, Hua S, Zhang Y. Scriptaid improves in vitro development and nuclear reprogramming of somatic cell nuclear transfer bovine embryos. Cell Reprogram. 2011 Oct;13(5):431–9. doi: 10.1089/cell.2011.0024.
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