CAS: 3153-37-5; Methyl 4-Chlorobutyrate

相似化合物

627-00-9 928-51-8 6139-84-0

上下游产品

CAS号67-56-1 甲醇 | CAS号4635-59-0 4-氯丁酰氯 | CAS号5891-21-4 5-氯-2-戊酮 | CAS号108-24-7 乙酸酐 | CAS号29006-02-8 4-甲氧基丁酸 | CAS号591235-25-5 γ-Diazobuttersa... | CAS号7647-01-0 盐酸 | CAS号628-20-6 4-氯丁腈 | CAS号627-00-9 4-氯丙酸 | CAS号623-42-7 丁酸甲酯 | CAS号28341-54-0 4-(4-硝基苯氧基)丁酸 | CAS号2327-68-6 DIMETHYL[3-(MET... | CAS号2868-37-3 环丙甲酸甲酯 | CAS号10385-30-5 4-苄氧基丁酸 | CAS号14273-85-9 4-碘丁酸甲酯 | CAS号13610-66-7 4-(2-氧代-1,3-苯并噁唑)丁酸 | CAS号6249-56-5 (3-羧丙基)三甲基氯化铵 | CAS号176375-42-1 methyl 4-(4-for... | CAS号113789-87-0 methyl 4-azido-... | CAS号2046-17-5 4-苯基丁酸甲酯

γ-Diazobuttersaeure-Methylester置于盐酸体系中,用 乙醚 作为反应溶剂,化学反应生成 4-氯丁酸甲酯
参考文献:Hauptmann,S.; Hirschberg,K.,Journal Fur Praktische Chemie (Leipzig 1954),1966,Vol. 34,P. 262-271
标题:Hauptmann,S.; Hirschberg,K.,Journal Fur Praktische Chemie (Leipzig 1954),1966,Vol. 34,P. 262-271

专利信息

专利号:US-8653238-B2
优先权日:2006-02-27
标题:Compositions and methods for transport of molecules with enhanced release properties across biological barriers
发明人：WENDER PAUL A; GOUN ELENA A; JONES LISA R
权利人:WENDER PAUL A; GOUN ELENA A; JONES LISA R; UNIV LELAND STANFORD JUNIOR
摘要:Conjugates of a cargo molecule with a transporter molecule are disclosed, where the cargo molecule and the transporter molecule are linked covalently by a releasable linker. The cargo of the conjugate can be a biologically active agent or a reporter molecule. The transporter modulates the transport of the cargo across a biological barrier (e.g., a cell membrane) compared to the transport of the unconjugated cargo. Releasable linkers suitable for rapid and facile conjugation to various types of cargo and transporters are also disclosed, along with methods for using the linkers in the synthesis of conjugates.

专利号:US-11214551-B2
优先权日:2018-04-27
标题 :One pot synthesis of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid, a key intermediate of zilpaterol
发明人：RAVI KUMAR KANNASANI; MALLIK YADAV KASA; SREENU MULU; BABU V V V
权利人:RA CHEM PHARMA LTD
摘要:The present invention relates to one pot process for the preparation of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid of Formula-I, which is a key intermediate and its use in the preparation of Zilpaterol, which comprises condensation of methyl-4-chloro butyrate with 1-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one in presence of a base and suitable solvent to give corresponding ester derivative, further hydrolyzation and acidification in presence of inorganic solvent to obtain Formula-I.

专利号:US-9303041-B2
优先权日:2012-08-21
标题 :Haptens of olanzapine
发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

专利号:US-2010292439-A1
优先权日:2006-07-05
标 题 :Use of Functionalized Onium Salts for Peptide Synthesis
发明人：VAULTIER MICHEL; ROCHE CELINE; GMOUH SAID; COMMERCON ALAIN
权利人:CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:A subject of the invention is the use of a salt with a dedicated task of formula (I): n A + -L-R—OY, X − n as soluble support for peptide synthesis, in which:n X − represents a functional or non-functional anion, Y represents either a hydrogen atom, or a —COOR 1 group, R 1 representing in particular an alkyl group comprising 1 to 20 carbon atoms, A + represents a cationic entity, L represents an arm, in particular an alkyl group of 3 to 20 carbon atoms, R represents in particular a group of formula —C(R a )(R b )—, R a and R b representing independently of one another in particular a hydrogen or an alkyl group, comprising 1 to 20 carbon atoms.

专利号:US-7453011-B2
优先权日:2001-12-07
标题:Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
发明人：CLIFFORD LINDA; VALASINAS ALDONIA L; BLOKHIN ANDREI V; SARKAR APARAJITA; BASU HIRAK S; REDDY VENODHAR K; MARTON LAURENCE J; WANG YU
权利人:PROGEN PHARMACEUTICALS INC
摘要:Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.

专利号:US-7129308-B2
优先权日:1998-10-13
标题 :Functionalized silicon compounds and methods for their synthesis and use
发明人：MCGALL GLENN; FORMAN JONATHAN ERIC
权利人:AFFYMETRIX INC
摘要:Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.