CAS: 3435-28-7; 6-Methylpyrimidin-4-Amine

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4-氯-6-甲基嘧啶置于ammonium Hydroxide体系中,化学反应 8.0H,反应生成 4-氨基-6-甲基嘧啶
参考文献:设计和合成一系列新型的4-杂芳基氨基-1'-氮杂螺[恶唑-5,3'-双环[2.2.2]辛烷作为α7烟碱样受体激动剂.2. 4-杂芳基sar的开发.
标题:设计和合成一系列新型的4-杂芳基氨基-1'-氮杂螺[恶唑-5,3'-双环[2.2.2]辛烷作为α7烟碱样受体激动剂.2. 4-杂芳基sar的开发.
摘要:如该系列以前的报告所述,含奎尼丁的螺环恶唑啉已证明可作为α7烟碱乙酰胆碱受体(α7Nachr)部分激动剂使用.在这项工作中,该化学型的sar被扩展为包括一系列的二嗪杂环取代.许多杂环类似物是α7受体的有效部分激动剂,对其他烟碱类受体和血清素5Ht3A受体具有选择性.(1'S,3'R,4'S)-N-(6-苯基嘧啶-4-基)-4H-1'-氮杂螺[恶唑-5,3'-双环[2.2.2]正辛]-2-胺,A有效和选择性的α7Nachr部分激动剂,被证明可以改善情节记忆的小鼠新对象识别(nor)模型中的认知.
DOI:10.1016/j.Bmcl.2017.01.058

专利信息

专利号:US-9751851-B2
优先权日:2013-09-20
标 题:Molecules and compositions that inhibit gram negative bacteria and their uses
发明人：BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T
权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T
摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.

专利号:US-3890321-A
优先权日:1971-09-20
标题 :6-aryl-5-ethyl-pyrimidin-4-ol compounds useful as intermediates and bronchodilators
发明人：DEANGELIS GERALD GEORGE; HESS HANS-JURGEN ERNST
权利人:PFIZER
摘要:4-Hydroxy-5-ethyl-6-arylpyrimidines are useful intermediates leading to the synthesis of 4-amino-5-ethyl-6-arylpyrimidines, inhibitors of platelet aggregation and bronchodilators. 4Hydroxy-5-ethyl-6-phenylpyrimidine is also useful as a bronchodilator.

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:CN-102105438-B
优先权日:2008-07-22
标题 :Process for the synthesis of substituted 4-amino-pyrimidines

专利号:US-11731956-B2
优先权日:2018-10-22
标 题:Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors

专利号:KR-20110049812-A
优先权日:2008-07-22
标题:Novel synthesis of substituted 4-amino-pyrimidines