CAS: 42518-98-9; 5-Chlorothiophene-2-Carbonyl Chloride

上下游产品

CAS号24065-33-6 2-氯噻吩-5-甲酸 | CAS号79-37-8 草酰氯 | CAS号6310-09-4 2-乙酰基-5-氯噻酚 | CAS号96-43-5 2-氯噻吩 | CAS号366789-02-8 利伐沙班 | CAS号351983-31-8 5-氯-2-噻吩甲酰肼 | CAS号22353-82-8 5-氯噻吩-2-甲酰胺 | CAS号24065-33-6 2-氯噻吩-5-甲酸 | CAS号5751-82-6 5-氯硫代苯-2-甲酸乙酯 | CAS号32427-82-0 1-(5-氯噻吩-2-基)-1-丙酮 | CAS号35475-03-7 5-氯噻吩-2-甲酸甲酯 | CAS号13669-19-7 2-(5-氯噻吩-2-基)乙酸 | CAS号869548-36-7 2-(5-氯噻吩-2-碳杂草酰... | CAS号873009-45-1 N-[(5-氯-2-噻吩基)羰基]甘氨酸

2-乙酰基-5-氯噻酚置于吡啶,Sulfur Monochloride体系中,用 氯苯 作为反应溶剂,化学反应 21.5H,反应生成 5-氯-2-酰氯噻吩
参考文献:一步一步将甲基酮转化为酰氯
标题:一步一步将甲基酮转化为酰氯
摘要:用单氯化硫和催化量的吡啶在回流的氯苯中处理芳族和杂芳族甲基酮会导致酰基氯的形成.富电子和贫电子的芳基甲基酮都可以用作起始原料.所得的c 1副产物取决于所选择的精确反应条件.
DOI:10.1021/acs.Joc.5B01707

专利信息

专利号:US-11891384-B2
优先权日:2017-01-04
标题:Process for the preparation of Rivaroxaban involving novel intermediate
发明人：SATHE DHANANJAY G; DAS ARIJIT; Raikar Sanjay; SURVE YASHWANT S; PANDIT BHUSHAN S
权利人:UNICHEM LAB LTD
摘要:The present invention relates to the novel key intermediate, 4-{4-[(SS)-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-phenyl}-morpholin-3-one perchlorate, m the synthesis of rivaroxaban. The invention further relates to the crystalline form of novel intermediate, the process to prepare the novel intermediate and method of preparing rivaroxaban using this novel intermediate. The invention provides an improved and efficient process for preparation of Rivaroxaban.

专利号:US-2006069260-A1
优先权日:2004-09-28
标 题:Preparation of N-aryl pyridones
发明人：ZHANG HUIPING; CHEN BANG-CHI; ZHAO RULIN
权利人:ZHANG HUIPING; CHEN BANG-CHI; ZHAO RULIN
摘要:A novel process and intermediates thereof for making N-aryl pyridones of the type shown below from appropriate pyridinolates is described. n nThese compounds are useful as intermediates for the synthesis of clinical candidates.

专利号:WO-2013046211-A1
优先权日:2011-09-27
标 题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

专利号:WO-2013027225-A1
优先权日:2011-08-19
标 题:Processes for the preparation of 4-{4-[5(s)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl} morpholin-3-one
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:The present invention provides simple, eco-friendly, cost-effective, reproducible, robust and industrial processes for the preparation of intermediate compound 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one (II). The present invention also provides novel intermediates and their use in the synthesis of morpholinone oxazolidine derivatives.

专利号:WO-2015198259-A1
优先权日:2014-06-26
标 题:Process for the synthesis of rivaroxaban and intermediate for the production thereof
发明人：FERRARI MASSIMO; GHEZZI EMANUELE; GHEZZI MARCELLO
权利人:ERREGIERRE SPA
摘要:A process is described for the production of Rivaroxaban, a compound having the following structural formula: (I) by means of obtaining a novel intermediate of said process.

专利号:RU-2383540-C2
优先权日:2004-01-15
标 题 :Method for synthesis of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide