CAS: 63927-22-0; 8-Bromoisoquinoline

相似化合物

81045-39-8 34784-04-8 34784-05-9

上下游产品

sulfuric acid (2-bromo-benzylidenamino)-acetaldehyde diethylacetal isoquinoline (2-bromobenzylidene)(2,2-dimethoxyethyl)amine isoquinoline-8-carbonitrile 8-bromo-2-oxidoisoquinolin-2-ium 8-(piperazin-1-yl)isoquinoline 8-bromo-1-(3,4-dimethoxy-benzyl)-isoquinoline

8-氨基异喹啉置于氢溴酸,Sodium Nitrite,Copper(I) Bromide体系中,用45%的收率获得产物8-溴异喹啉
参考文献:C-5-和c-8-取代的1-(3,4-二甲氧基苄基)-2,2-二甲基-1,2,3,4-四氢异喹啉鎓作为与n-甲基相关的sk通道阻滞剂的合成及放射性配体结合研究-月桂肌苷和n-甲基-Noscapine.
标题:C-5-和c-8-取代的1-(3,4-二甲氧基苄基)-2,2-二甲基-1,2,3,4-四氢异喹啉鎓作为与n-甲基相关的sk通道阻滞剂的合成及放射性配体结合研究-月桂肌苷和n-甲基-Noscapine.
摘要:原始c-5-和c-8取代的1-(3,4-二甲氧基-苄基)-2,2-二甲基-1,2,3,4-的合成及(125)i-氨基甲酰胺的结合研究为了找到可逆的选择性sk通道阻滞剂,进行了四氢异喹啉鎓和1-(3,4-二甲氧基-苄基)-6,6-二甲基-4,5,6,7-四氢噻吩并[2,3-C]吡啶鎓的研究在结构上与n-甲基-月桂氨酸和n-甲基-芥子碱有关.在四氢异喹啉的c-8位上的大体积烷基取代基使对apapamin敏感的结合位点的亲和力明显增加.在c-5和c-8位置存在一个吸电子基团,并不适合替代与n-甲基-月桂丹碱结构相关的药物的亲和力.噻吩类似物和8-甲氧基衍生物对甜菜素敏感的结合位点具有较弱的亲和力.
DOI:10.1021/jm049025P

专利信息

专利号:US-6500954-B1
优先权日:1998-06-22
标 题:Synthesis of 5- or 8-bromoisoquinoline derivatives
发明人：GOULIAEV ALEX HAAHR; HANSEN WILLIAM
权利人:NEUROSEARCH AS
摘要:The present invention is directed to a method of preparing bromoisoquinoline derivatives, in particular 5- or 8-bromoisoquinoline derivatives. Bromoisoquinoline derivatives, and in particular 5-bromoisoquinoline and 5-bromo-8-nitroisoquinoline derivatives, are key intermediates in the synthesis of pharmaceutical compounds.

专利号:US-9884844-B2
优先权日:2012-12-31
标 题:Heterocyclic compounds and methods of use thereof
发明人：FANG QUN KEVIN; CAMPBELL UNA; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

专利号:DE-69911603-D1
优先权日:1998-06-22
标题:SYNTHESIS OF 5- OR 8-BROMOISOQUINOLINE DERIVATIVES

专利号:DE-69911603-T2
优先权日:1998-06-22
标题:SYNTHESIS OF 5- OR 8-BROMOISOQUINOLINE DERIVATIVES

专利号:AT-E250584-T1
优先权日:1998-06-22
标题:SYNTHESIS OF 5-OR 8-BROMOISOQUINOLINE DERIVATIVES

专利号:CN-104447547-B
优先权日:2014-11-10
标 题:Synthesis method of 4-aminoisoquinoline-8-methyl formate