专利号:US-9315483-B2 优先权日:2007-09-13 标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof 发明人:JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT 权利人:CONCERT PHARMACEUTICALS INC 摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.
专利号:US-7652172-B2 优先权日:2004-09-20 标题:Expeditious synthesis of DPD 发明人:SEMMELHACK MARTIN F; CAMPAGNA SHAWN R; BASSLER BONNIE L; FEDERLE MICHAEL J 权利人:UNIV PRINCETON 摘要:This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.
专利号:US-2024309003-A1 优先权日:2021-05-04 标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use 发明人:HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN 权利人:VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
专利号:US-2009234121-A1 优先权日:2008-01-16 标 题 :Tridentate (nnc) catalysts for the selective oxidation of hydrocarbons 发明人:PERIANA ROY A; GODDARD III WILLIAM A; OXGAARD JONAS; YOUNG KENNETH 权利人:PERIANA ROY A; GODDARD III WILLIAM A; OXGAARD JONAS; YOUNG KENNETH 摘要:The synthesis of discrete, air, protic, and thermally stable transition metal NNC complexes that catalyze the CH activation and functionalization of alkanes and arenes is disclosed. Methods for the selective conversion of methane to methanol or methyl esters in acidic and neutral media are disclosed.
专利号:US-2024286990-A1 优先权日:2021-06-18 标题:Vinylated keto esters with applicability in signal enhanced magnetic resonance imaging and synthesis thereof 发明人:GLÖGGLER STEFAN; KORCHAK SERGEY; JAGTAP ANIL P; SAUL PHILIP; MOLL DENIS 权利人:MAX PLANCK GESELLSCHAFT 摘要:The present invention relates to a vinyl keto ester and intermediates of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediates is partly or fully deuterated. Furthermore, the present invention relates to two alternative methods of preparing said vinyl keto ester. The first method is a multi-step approach comprising the steps of providing a carboxylic acid that comprises a geminal diol moiety protected by a photolabile protecting group, vinylating said carboxylic acid using vinyl acetate, and cleaving the protecting group by applying UV light. The second method is a one-step approach of reacting a carboxylic acid that comprises an additional carbonyl moiety with acetylene in the presence of a metal catalyst. In both methods, the compounds used may be fully or partly deuterated.
专利号:WO-2009035652-A1 优先权日:2007-09-13 标 题 :Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
参考标题:Substituted Dihydropyridine Synthesis By Dearomatization Of Pyridines 作者:Arne Heusler,Julian Fliege,Tobias Wagener,Frank Glorius |发布日期:2021.6.14 摘要:Sensitive Reagents Restricts The Applicability In Synthetic Laboratories. Herein, We Report The Synthesis Of A Broad Variety Of N-Substituted 1,4- And 1,2-Dihydropyridines By Very Mild And Selective Reduction With Amine Borane For The First Time.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026). 参考文献:10.1038/s41563-020-0764-y 摘要:Knebel A, Bavykina A, Datta SJ, Sundermann L, Garzon-Tovar L, Lebedev Y, Durini S, Ahmad R, Kozlov SM, Shterk G, Karunakaran M, Carja ID, Simic D, Weilert I, Klüppel M, Giese U, Cavallo L, Rueping M, Eddaoudi M, Caro J, Gascon J. Solution processable metal-organic frameworks for mixed matrix membranes using porous liquids. Nat Mater. 2020 Dec;19(12):1346–53. doi: 10.1038/s41563-020-0764-y.